Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1874864..1876578 Replicon chromosome
Accession NZ_CP037952
Organism Parashewanella spongiae strain HJ039

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag E2I05_RS07225 Protein ID WP_121855103.1
Coordinates 1875235..1876578 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag E2I05_RS07220 Protein ID WP_121855102.1
Coordinates 1874864..1875235 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2I05_RS07195 1871776..1872072 + 297 WP_133309543.1 hypothetical protein -
E2I05_RS07200 1872045..1873160 + 1116 Protein_1406 transposase -
E2I05_RS07205 1873552..1874394 + 843 WP_133309544.1 IS4 family transposase -
E2I05_RS07210 1874450..1874635 + 186 WP_133309406.1 hypothetical protein -
E2I05_RS07215 1874660..1874833 + 174 WP_133309545.1 hypothetical protein -
E2I05_RS07220 1874864..1875235 - 372 WP_121855102.1 helix-turn-helix domain-containing protein Antitoxin
E2I05_RS07225 1875235..1876578 - 1344 WP_121855103.1 type II toxin-antitoxin system HipA family toxin Toxin
E2I05_RS07230 1877068..1878804 + 1737 WP_121855104.1 hypothetical protein -
E2I05_RS07235 1878913..1879164 + 252 WP_165905577.1 hypothetical protein -
E2I05_RS07240 1880627..1880848 + 222 WP_121855106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-400)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51212.01 Da        Isoelectric Point: 4.8275

>T120551 WP_121855103.1 NZ_CP037952:c1876578-1875235 [Parashewanella spongiae]
MKHLTVQAFLDKQWKDVGDIAFPYGNKNKFNVAEFIYNDDYVIEYIDKDDEYAVSLNYPVALFFDTVNKTWPGFIDDIMP
SGASRRYWMKYLGLEGIPLDEQNYLLLKNGTMSPVGNLRIKESLPQKNPLAENLFFTIEDVVNRAGDFLDYAQQRGAVAG
GATGAGGEAPKLLLRCNEKQQIWIDTYQDDLTNQDIHYLVKYPRGSRAEIDCDILRAEYHFYHELDTMGFSTIATDNMRL
EEGIKYPSIWLPRFDVECDQNGLNRFGMESVYSILNKAAGTTLYHGTVIRELITKITHSYMVEKQSFKFDQQKFVIEWVN
RDLLNIVFGNSDNHGRNTSFIRHQGEIRLAPIYDFAPMKADPEGVARTTIWGNSLEIGGEYNFVAIADSLAEFVDKDVLL
NSLNKTAKQLIDLQSRLEQRGVPEQILSMPSIGFDFITEKLTRWGLR

Download         Length: 1344 bp

>T120551 NZ_CP037952:c1876578-1875235 [Parashewanella spongiae]
ATGAAGCATCTTACTGTACAGGCTTTTTTAGATAAGCAATGGAAAGATGTTGGGGATATCGCCTTTCCATATGGCAACAA
AAACAAATTCAATGTGGCGGAATTCATCTACAACGATGACTATGTTATTGAGTATATAGATAAAGATGACGAATACGCTG
TTTCACTCAATTATCCAGTAGCCTTATTCTTTGACACTGTAAATAAAACATGGCCTGGCTTTATTGATGACATTATGCCT
AGCGGTGCGAGCAGACGCTATTGGATGAAATATTTGGGACTTGAAGGGATCCCCCTTGATGAGCAAAATTACCTACTACT
AAAAAATGGCACAATGTCACCGGTAGGAAATCTTCGCATTAAAGAGTCCTTGCCTCAAAAAAACCCGTTGGCAGAAAACC
TTTTCTTCACCATTGAAGACGTCGTTAATCGTGCGGGTGACTTTTTAGATTATGCTCAACAAAGAGGAGCTGTAGCTGGC
GGTGCAACTGGTGCTGGTGGTGAAGCACCAAAGCTACTATTACGCTGCAATGAAAAGCAGCAAATTTGGATAGATACCTA
CCAAGATGACTTAACCAACCAAGATATTCATTATTTGGTGAAATATCCTAGAGGCTCACGAGCTGAGATCGATTGTGACA
TCTTACGAGCCGAGTACCATTTTTATCACGAGCTTGACACTATGGGATTCAGCACCATAGCAACCGATAATATGCGTCTG
GAAGAAGGCATAAAGTATCCGTCTATTTGGTTACCAAGATTTGACGTTGAATGTGATCAGAATGGCCTGAATCGCTTTGG
AATGGAGTCTGTCTACTCAATACTTAATAAAGCTGCAGGAACAACGCTTTATCATGGAACCGTTATTCGTGAGCTAATAA
CAAAGATCACACATTCTTATATGGTCGAAAAACAAAGCTTCAAGTTTGATCAGCAAAAATTTGTTATCGAGTGGGTAAAC
AGAGACTTACTTAATATCGTATTTGGTAATAGCGACAACCATGGCAGAAACACCTCGTTTATACGTCATCAAGGTGAGAT
ACGGTTAGCACCAATTTACGACTTTGCACCAATGAAAGCCGATCCTGAAGGTGTTGCCAGAACAACCATTTGGGGCAATT
CATTAGAAATTGGTGGAGAGTATAATTTCGTTGCTATTGCCGATTCATTAGCCGAATTCGTTGATAAAGATGTGTTACTG
AATTCACTCAACAAAACCGCTAAGCAACTCATTGATTTACAGTCACGACTTGAACAGAGAGGTGTTCCTGAGCAAATTTT
ATCAATGCCAAGCATTGGCTTTGACTTCATAACCGAAAAACTCACACGTTGGGGGCTACGTTAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 13960.32 Da        Isoelectric Point: 10.6617

>AT120551 WP_121855102.1 NZ_CP037952:c1875235-1874864 [Parashewanella spongiae]
MEDTKPKELSTPMRKRTSKTTKGVSTFERNQKIREVIFKVVTSELTQGQALKVLRMDIIGLKQDAYAKLVKVSRKTISEI
ENDRGNYTAEVVNKVFKPFGLKVGLMPRSPQLLATLFTELNSE

Download         Length: 372 bp

>AT120551 NZ_CP037952:c1875235-1874864 [Parashewanella spongiae]
ATGGAAGATACAAAGCCAAAAGAACTCAGTACACCGATGAGAAAACGTACCTCAAAAACAACAAAAGGTGTGAGCACATT
TGAGAGAAACCAAAAAATCCGTGAAGTGATCTTTAAGGTAGTGACTTCTGAGCTTACTCAAGGGCAAGCTTTGAAGGTTT
TGCGAATGGACATCATTGGTTTAAAGCAAGATGCTTATGCTAAGTTAGTGAAAGTGTCTCGTAAAACCATTTCTGAGATT
GAAAATGACCGTGGCAATTATACCGCTGAAGTGGTCAATAAAGTCTTTAAGCCGTTTGGTTTGAAAGTAGGGTTAATGCC
GAGATCGCCTCAGTTATTAGCAACGCTTTTTACAGAACTAAACTCAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References