120550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 1219920..1220935 Replicon chromosome
Accession NZ_CP037952
Organism Parashewanella spongiae strain HJ039

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag E2I05_RS04520 Protein ID WP_121853057.1
Coordinates 1220366..1220935 (+) Length 190 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag E2I05_RS04515 Protein ID WP_121853056.1
Coordinates 1219920..1220366 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2I05_RS04490 1215211..1215837 - 627 WP_121854903.1 peptide chain release factor H -
E2I05_RS04495 1215834..1217000 - 1167 WP_121854904.1 RNA ligase RtcB family protein -
E2I05_RS04500 1217352..1218122 - 771 WP_121854905.1 tyrosine-type recombinase/integrase -
E2I05_RS04505 1218210..1219355 + 1146 WP_133309417.1 ISAs1 family transposase -
E2I05_RS04515 1219920..1220366 + 447 WP_121853056.1 helix-turn-helix domain-containing protein Antitoxin
E2I05_RS04520 1220366..1220935 + 570 WP_121853057.1 PIN domain-containing protein Toxin
E2I05_RS04525 1221110..1221832 - 723 WP_121853058.1 helix-turn-helix domain-containing protein -
E2I05_RS04530 1221890..1222090 + 201 WP_121853059.1 DNA-binding protein -
E2I05_RS04535 1222157..1222675 + 519 WP_165905462.1 phage regulatory CII family protein -
E2I05_RS04540 1222690..1223064 + 375 WP_121853061.1 hypothetical protein -
E2I05_RS04545 1223121..1223381 + 261 WP_121853062.1 hypothetical protein -
E2I05_RS04550 1223409..1225406 + 1998 WP_121853063.1 replication endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1215834..1225406 9572


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-113)

Antitoxin

Helix-turn-helix domain, group 17

(78-125)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 21462.64 Da        Isoelectric Point: 5.2635

>T120550 WP_121853057.1 NZ_CP037952:1220366-1220935 [Parashewanella spongiae]
MATYTVIFDACVMYPAPLRSLLMYLANTDLFRARWTDQIHDEWIRNLLNNNPSVTEAGLDKVRKLMNSHIPDCLIEGYET
LIDGITLPDVDDRHVVAAAIKGQAESIITFNLKDFPSSALDVYDIYAVHPDEFLSDMFELDASKVIDAARKHRASLRKPA
LTANEYLDCLQRQKLPNFVSKLRSFAITI

Download         Length: 570 bp

>T120550 NZ_CP037952:1220366-1220935 [Parashewanella spongiae]
ATGGCTACCTACACCGTAATCTTTGATGCATGCGTAATGTACCCAGCACCTTTACGCAGTCTATTGATGTATTTAGCAAA
CACTGACTTATTCAGGGCTCGCTGGACTGATCAAATTCACGATGAATGGATTAGAAATCTTCTAAATAATAACCCCTCAG
TAACTGAAGCTGGATTAGATAAAGTACGGAAGCTAATGAACTCTCATATTCCTGATTGTTTGATTGAAGGCTACGAAACC
CTAATAGACGGGATCACTCTGCCAGATGTAGATGATAGACATGTAGTAGCAGCTGCAATCAAAGGGCAAGCTGAGTCAAT
CATTACATTCAACCTCAAAGACTTTCCTTCTTCAGCACTTGATGTATACGATATTTATGCTGTTCATCCAGATGAATTCT
TAAGTGATATGTTTGAACTTGATGCAAGTAAAGTTATTGACGCAGCTCGAAAGCATAGAGCTAGTCTAAGAAAACCAGCT
TTAACAGCCAATGAATACCTTGATTGTTTGCAACGGCAGAAGCTACCAAACTTTGTTTCGAAGCTGAGAAGCTTTGCTAT
TACGATTTGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16102.55 Da        Isoelectric Point: 5.2305

>AT120550 WP_121853056.1 NZ_CP037952:1219920-1220366 [Parashewanella spongiae]
MAITIPSAEEVALAKLGSQELSAFIDVDGSPQKISVLDKAGQKHEVSLPASALKLMVDILTELGQGNSVNITPIHAELTT
QEGADMLNMSRPTFIKLLDNLAIPFHRKGNRRKVAFSDVLAYKQSLKDKRLEALDELSALDQELGMGY

Download         Length: 447 bp

>AT120550 NZ_CP037952:1219920-1220366 [Parashewanella spongiae]
ATGGCAATTACAATACCGAGTGCGGAAGAAGTTGCTTTAGCAAAACTTGGTAGTCAGGAGCTTTCAGCATTTATTGATGT
TGATGGTAGCCCACAAAAAATTAGTGTTCTTGATAAAGCAGGGCAAAAGCATGAAGTGAGTTTACCAGCGAGTGCATTAA
AACTGATGGTTGATATATTAACTGAACTAGGTCAGGGTAATTCTGTGAATATCACACCAATTCATGCTGAACTTACGACT
CAAGAAGGTGCTGACATGCTCAATATGTCACGTCCTACGTTTATTAAATTATTGGATAACTTGGCAATTCCTTTTCACCG
TAAGGGTAATAGGAGAAAAGTCGCTTTCTCTGATGTGTTAGCTTACAAGCAGTCTCTTAAAGATAAAAGACTTGAAGCTT
TAGACGAACTTTCAGCGCTAGATCAGGAATTAGGTATGGGTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References