Detailed information of TA system TA120548

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 3871975..3872526
• Replicon: chromosome
• Accession: NZ_CP037951
• Organism: Parashewanella tropica strain MEBiC05444

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E2H97_RS17075
• Protein ID: WP_133408251.1
• Coordinates: 3872224..3872526 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: E2H97_RS17070
• Protein ID: WP_133408250.1
• Coordinates: 3871975..3872217 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2H97_RS17045	3868097..3868867	+	771	WP_133408247.1	divergent polysaccharide deacetylase family protein	-
E2H97_RS17050	3868839..3869090	-	252	WP_133408248.1	YkgJ family cysteine cluster protein	-
E2H97_RS17055	3869277..3871187	+	1911	WP_133408249.1	hypothetical protein	-
E2H97_RS17060	3871306..3871497	+	192	WP_133408694.1	hypothetical protein	-
E2H97_RS17065	3871545..3871799	-	255	WP_133408695.1	helix-turn-helix domain-containing protein	-
E2H97_RS17070	3871975..3872217	+	243	WP_133408250.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E2H97_RS17075	3872224..3872526	+	303	WP_133408251.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E2H97_RS17080	3873219..3873596	-	378	WP_133408252.1	hypothetical protein	-
E2H97_RS17085	3873972..3874457	-	486	WP_133408253.1	hypothetical protein	-
E2H97_RS17090	3874966..3875298	+	333	WP_133408254.1	TrbC/VirB2 family protein	-
E2H97_RS17095	3875311..3875631	+	321	WP_133408255.1	VirB3 family type IV secretion system protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	3871268..3942240	70972

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11604.51 Da
• Isoelectric Point: 9.4019

>T120548 WP_133408251.1 NZ_CP037951:3872224-3872526 [Parashewanella tropica]
MKDQKFKLSKLAQMHLQKIKNYTIEHFSEPQWHSYKEMLLSGFQMLADNPDLGINCDEIYSGGFRFPIGKHMAYFTKEDG
FILVAAVLGQSQLPQKHLKK

Nucleotide

• Length: 303 bp

>T120548 NZ_CP037951:3872224-3872526 [Parashewanella tropica]
ATGAAAGATCAAAAATTTAAACTGAGTAAGTTAGCTCAGATGCACTTACAAAAAATAAAAAACTATACCATTGAACACTT
CTCTGAACCTCAATGGCACAGTTATAAAGAAATGCTTTTATCAGGCTTTCAGATGCTCGCAGACAACCCCGATCTTGGTA
TCAATTGTGACGAGATATATTCCGGCGGCTTTCGATTTCCTATCGGTAAACACATGGCATACTTCACCAAAGAAGATGGT
TTTATTTTAGTAGCTGCCGTATTAGGACAATCGCAGCTGCCTCAAAAGCATCTGAAAAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9018.34 Da
• Isoelectric Point: 6.4616

>AT120548 WP_133408250.1 NZ_CP037951:3871975-3872217 [Parashewanella tropica]
MHTLTANDAKRNFGELLLSAQREPIKISKNSKDTVVVMSIKDYEELETMKAEYLKHCFESAKEDLAKGNIVDGKSFLNAL

Nucleotide

• Length: 243 bp

>AT120548 NZ_CP037951:3871975-3872217 [Parashewanella tropica]
ATGCACACATTAACAGCCAATGATGCTAAGCGTAATTTTGGTGAATTACTGCTAAGCGCACAGCGTGAACCTATAAAGAT
CAGCAAAAACAGTAAAGATACCGTTGTTGTTATGTCTATTAAAGACTACGAAGAGCTTGAAACGATGAAAGCTGAATATC
TTAAACACTGCTTTGAATCGGCTAAAGAAGATTTAGCTAAAGGCAATATTGTTGACGGTAAAAGCTTCCTAAATGCGTTA
TAA