Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3859757..3860391 Replicon chromosome
Accession NZ_CP037951
Organism Parashewanella tropica strain MEBiC05444

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E2H97_RS17000 Protein ID WP_133408240.1
Coordinates 3859757..3860158 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E2H97_RS17005 Protein ID WP_133408241.1
Coordinates 3860158..3860391 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2H97_RS16980 3855636..3856565 - 930 WP_133408236.1 ABC transporter ATP-binding protein -
E2H97_RS16985 3856562..3857545 - 984 WP_133408237.1 HlyD family efflux transporter periplasmic adaptor subunit -
E2H97_RS16990 3857954..3858445 + 492 WP_133408238.1 hypothetical protein -
E2H97_RS16995 3858606..3859568 - 963 WP_133408239.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
E2H97_RS17000 3859757..3860158 - 402 WP_133408240.1 tRNA(fMet)-specific endonuclease VapC Toxin
E2H97_RS17005 3860158..3860391 - 234 WP_133408241.1 antitoxin Antitoxin
E2H97_RS17010 3860448..3861629 - 1182 WP_133408242.1 NAD(P)/FAD-dependent oxidoreductase -
E2H97_RS17015 3861713..3862726 - 1014 WP_133408243.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
E2H97_RS17020 3862730..3863227 - 498 WP_121839947.1 protein-export chaperone SecB -
E2H97_RS17025 3863435..3863869 - 435 WP_133408244.1 rhodanese-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15125.42 Da        Isoelectric Point: 7.3212

>T120547 WP_133408240.1 NZ_CP037951:c3860158-3859757 [Parashewanella tropica]
MFRYLLDTNIVIYVIKRRPIEVLDTFNANAGLMCINSITYAELMHGVEKSTKPVENRRLVQDFVSRLSVLDYGMKAAEHY
GDIRAHLEKQGKTIGINDLHIAASARSEGLIVVTNNECEFSRVDGLRVENWVK

Download         Length: 402 bp

>T120547 NZ_CP037951:c3860158-3859757 [Parashewanella tropica]
ATGTTTCGATATTTGCTCGATACTAACATTGTTATCTACGTCATAAAGCGCCGTCCGATTGAAGTACTTGATACTTTTAA
TGCCAATGCTGGGCTTATGTGTATTAATAGCATCACCTATGCTGAACTGATGCATGGTGTTGAAAAAAGTACTAAGCCAG
TTGAGAATCGCAGACTTGTTCAAGACTTTGTTTCTCGATTATCGGTGCTCGATTACGGTATGAAGGCGGCAGAGCATTAT
GGTGATATCAGAGCTCATTTAGAAAAGCAGGGTAAAACCATAGGCATAAATGATCTACACATTGCAGCTAGTGCCAGAAG
TGAAGGTTTGATAGTCGTTACAAATAATGAATGTGAATTCAGTCGAGTTGATGGCTTACGTGTTGAGAACTGGGTGAAAT
AA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8859.77 Da        Isoelectric Point: 4.3533

>AT120547 WP_133408241.1 NZ_CP037951:c3860391-3860158 [Parashewanella tropica]
MSSGTVFKNNNTQAVRLPKDARFDDDVKKVNVRVVGSERILTPVEKTWDSFFLSEETVSEDFMVERADQAQDDRESF

Download         Length: 234 bp

>AT120547 NZ_CP037951:c3860391-3860158 [Parashewanella tropica]
ATGTCTAGTGGAACCGTATTTAAAAATAATAATACTCAAGCAGTACGCTTGCCGAAAGACGCTCGTTTTGATGACGATGT
TAAAAAGGTCAATGTTCGTGTTGTCGGGAGTGAACGGATCTTAACGCCAGTGGAAAAAACATGGGACAGCTTTTTCCTTT
CTGAAGAAACGGTAAGTGAAGATTTTATGGTAGAGCGTGCCGATCAAGCCCAAGATGACAGGGAGTCATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References