Detailed information of TA system TA120544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4605056..4605675
• Replicon: chromosome
• Accession: NZ_CP037950
• Organism: Erwinia sp. QL-Z3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: E2F51_RS22090
• Protein ID: WP_105760677.1
• Coordinates: 4605496..4605675 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: D8MUK4
• Locus tag: E2F51_RS22085
• Protein ID: WP_013202996.1
• Coordinates: 4605056..4605466 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2F51_RS22065	4600397..4601089	+	693	WP_013202992.1	CidB/LrgB family autolysis modulator	-
E2F51_RS22070	4601218..4602102	+	885	WP_134824581.1	cytidine deaminase	-
E2F51_RS22075	4602269..4603966	+	1698	WP_013202994.1	NAD-dependent malic enzyme	-
E2F51_RS22080	4604130..4604996	+	867	WP_013202995.1	outer membrane permeability protein SanA	-
E2F51_RS22085	4605056..4605466	-	411	WP_013202996.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E2F51_RS22090	4605496..4605675	-	180	WP_105760677.1	type II toxin-antitoxin system HicA family toxin	Toxin
E2F51_RS22095	4605895..4606905	-	1011	WP_013202998.1	galactose/methyl galactoside ABC transporter permease MglC	-
E2F51_RS22100	4606925..4608445	-	1521	WP_013202999.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
E2F51_RS22105	4608542..4609537	-	996	WP_134824582.1	galactose/glucose ABC transporter substrate-binding protein MglB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6691.91 Da
• Isoelectric Point: 11.0775

>T120544 WP_105760677.1 NZ_CP037950:c4605675-4605496 [Erwinia sp. QL-Z3]
MDSRTLIAEIKADGWELIRVNGSHHHFRHPTKKGVVTIPHPKKDLPIKTIKSIKKQAGM

Nucleotide

• Length: 180 bp

>T120544 NZ_CP037950:c4605675-4605496 [Erwinia sp. QL-Z3]
ATGGATAGCAGGACGTTAATCGCTGAAATCAAAGCTGACGGTTGGGAACTGATTAGGGTAAATGGAAGTCATCATCATTT
CAGGCACCCCACCAAAAAAGGGGTAGTGACTATCCCCCATCCAAAGAAAGATTTACCCATAAAAACGATAAAGAGTATTA
AGAAACAAGCGGGGATGTAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14559.55 Da
• Isoelectric Point: 4.3937

>AT120544 WP_013202996.1 NZ_CP037950:c4605466-4605056 [Erwinia sp. QL-Z3]
MLYPIAIENGDEHHAYGVTVPDLPGCFSAGETLEEAVNNAKEAITGHIELLIELGDDIPAVSSLSALVADSQYAGYTWAL
VDVDLARLLGGTEKINVTLPKSLIDRIDRCVATHPEFKSRSGFLAQVAIERIAKGV

Nucleotide

• Length: 411 bp

>AT120544 NZ_CP037950:c4605466-4605056 [Erwinia sp. QL-Z3]
ATGCTATATCCAATTGCTATTGAGAACGGTGACGAGCACCATGCTTACGGCGTGACCGTGCCAGATTTGCCCGGTTGTTT
TTCTGCCGGAGAAACGTTAGAAGAAGCCGTGAACAATGCCAAAGAGGCGATTACTGGACATATTGAATTGCTTATCGAGC
TGGGTGACGATATTCCGGCCGTATCCTCCCTGAGCGCTCTTGTTGCCGATAGTCAGTATGCTGGCTATACCTGGGCGCTT
GTCGATGTGGACCTGGCCCGGCTCTTAGGGGGCACTGAGAAAATCAACGTGACTTTACCGAAGTCACTTATTGACCGTAT
AGATCGCTGTGTGGCCACACACCCTGAGTTTAAAAGCCGTTCTGGTTTCCTTGCTCAGGTGGCGATTGAGCGTATTGCGA
AAGGCGTTTAA

Structures

Antitoxin

• AlphaFold DB: D8MUK4