Detailed information of TA system TA120539

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 436166..436811
• Replicon: chromosome
• Accession: NZ_CP037950
• Organism: Erwinia sp. QL-Z3

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: E2F51_RS02660
• Protein ID: WP_053143651.1
• Coordinates: 436166..436564 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D8MWF5
• Locus tag: E2F51_RS02665
• Protein ID: WP_013203646.1
• Coordinates: 436545..436811 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2F51_RS02640	432086..433804	-	1719	WP_134822667.1	single-stranded-DNA-specific exonuclease RecJ	-
E2F51_RS02645	433810..434514	-	705	WP_053143720.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
E2F51_RS02650	434566..435459	-	894	WP_134822668.1	site-specific tyrosine recombinase XerD	-
E2F51_RS02655	435558..436076	+	519	WP_053143653.1	flavodoxin FldB	-
E2F51_RS02660	436166..436564	-	399	WP_053143651.1	protein YgfX	Toxin
E2F51_RS02665	436545..436811	-	267	WP_013203646.1	FAD assembly factor SdhE	Antitoxin
E2F51_RS23775	436831..437004	-	174	WP_157868033.1	hypothetical protein	-
E2F51_RS02670	437029..438012	+	984	WP_134822669.1	tRNA-modifying protein YgfZ	-
E2F51_RS02675	438053..438706	-	654	WP_013203648.1	hemolysin III family protein	-
E2F51_RS02680	438968..439576	+	609	WP_013203650.1	HD domain-containing protein	-
E2F51_RS02685	439576..440304	+	729	WP_053143642.1	MurR/RpiR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	366420..445957	79537

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-130)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15731.63 Da
• Isoelectric Point: 11.1373

>T120539 WP_053143651.1 NZ_CP037950:c436564-436166 [Erwinia sp. QL-Z3]
VALWHSDLRISWRAQWISLLLHGVVILALLLAPWPASFTLVWMLLLTLVVFECVRSQRRIRSREGVISLLEHQQMQWRQK
RWQICGRPWMTRQAIFLKLSSAKGEKEKLWLCRDSMDEDDWRALRQQLLTPG

Nucleotide

• Length: 399 bp

>T120539 NZ_CP037950:c436564-436166 [Erwinia sp. QL-Z3]
GTGGCCCTGTGGCACTCTGATTTACGGATCTCATGGCGTGCTCAGTGGATTTCTCTGTTGCTGCACGGCGTGGTGATCCT
TGCGCTGTTGCTCGCGCCCTGGCCTGCCAGTTTCACCCTGGTGTGGATGCTGCTGCTGACGCTGGTGGTGTTTGAATGCG
TGCGCAGCCAGCGGCGGATCCGCAGTCGTGAAGGCGTGATTTCGCTGCTTGAGCATCAGCAAATGCAGTGGCGGCAGAAG
CGCTGGCAGATTTGTGGCCGCCCGTGGATGACCCGACAGGCGATTTTCCTGAAATTAAGCTCAGCGAAAGGCGAGAAGGA
AAAACTGTGGTTGTGCCGCGACAGCATGGATGAAGACGACTGGCGGGCATTGCGTCAGCAGTTGCTGACGCCGGGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10456.90 Da
• Isoelectric Point: 4.7921

>AT120539 WP_013203646.1 NZ_CP037950:c436811-436545 [Erwinia sp. QL-Z3]
MDISNRARVHWACRRGMLELDIAIMPFFKFEYDTLDDNDKQQFVRLLESPDPDLFNWLMNHGEPDDAELKRIVNLIQQRN
QQRGPVAL

Nucleotide

• Length: 267 bp

>AT120539 NZ_CP037950:c436811-436545 [Erwinia sp. QL-Z3]
ATGGATATTAGTAACAGAGCACGGGTTCACTGGGCGTGCCGCCGTGGCATGCTTGAACTGGATATCGCCATCATGCCGTT
CTTCAAGTTTGAGTACGATACGCTGGACGACAATGACAAACAGCAGTTCGTGCGTCTGCTCGAAAGCCCCGATCCTGACC
TCTTTAACTGGCTGATGAATCACGGTGAGCCGGATGATGCTGAGCTGAAGCGGATAGTCAATTTGATACAACAGCGAAAT
CAGCAACGTGGCCCTGTGGCACTCTGA

Structures

Antitoxin

• AlphaFold DB: D8MWF5