Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1231613..1232448 Replicon chromosome
Accession NZ_CP037943
Organism Escherichia coli strain CFSAN027343

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag EKI57_RS06810 Protein ID WP_000854757.1
Coordinates 1232071..1232448 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag EKI57_RS06805 Protein ID WP_001295723.1
Coordinates 1231613..1231981 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKI57_RS06760 1227720..1228067 - 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
EKI57_RS06765 1228064..1228468 - 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
EKI57_RS06770 1228557..1228898 + 342 WP_072097794.1 hypothetical protein -
EKI57_RS06775 1228977..1229210 + 234 WP_001119729.1 DUF905 family protein -
EKI57_RS06785 1229310..1230128 + 819 WP_001234620.1 DUF945 domain-containing protein -
EKI57_RS06790 1230183..1230668 + 486 WP_000849582.1 antirestriction protein -
EKI57_RS06795 1230684..1231160 + 477 WP_001186725.1 RadC family protein -
EKI57_RS06800 1231229..1231450 + 222 WP_000692323.1 DUF987 domain-containing protein -
EKI57_RS06805 1231613..1231981 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EKI57_RS06810 1232071..1232448 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
EKI57_RS06815 1232445..1232648 + 204 WP_000761705.1 hypothetical protein -
EKI57_RS06820 1232661..1232774 + 114 WP_001161660.1 DUF957 domain-containing protein -
EKI57_RS06825 1232933..1233961 + 1029 Protein_1306 IS110 family transposase -
EKI57_RS06835 1234415..1234597 + 183 WP_024167529.1 ethanolamine utilization protein -
EKI57_RS06840 1234698..1235027 - 330 WP_000450409.1 DUF496 family protein -
EKI57_RS06845 1235199..1236257 - 1059 WP_001200887.1 FUSC family protein -
EKI57_RS06850 1236455..1236928 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T120480 WP_000854757.1 NZ_CP037943:1232071-1232448 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T120480 NZ_CP037943:1232071-1232448 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT120480 WP_001295723.1 NZ_CP037943:1231613-1231981 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT120480 NZ_CP037943:1231613-1231981 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References