Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3928290..3929125 Replicon chromosome
Accession NZ_CP037941
Organism Escherichia coli strain CFSAN027350

Toxin (Protein)


Gene name yeeV Uniprot ID A0A136X5A2
Locus tag EKI55_RS20085 Protein ID WP_000854757.1
Coordinates 3928748..3929125 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag EKI55_RS20080 Protein ID WP_001295723.1
Coordinates 3928290..3928658 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EKI55_RS20045 3923653..3924093 + 441 Protein_3824 DUF932 domain-containing protein -
EKI55_RS20050 3924148..3924633 + 486 WP_000849582.1 antirestriction protein -
EKI55_RS20055 3924649..3925149 + 501 WP_133374437.1 RadC family protein -
EKI55_RS20060 3925153..3926724 - 1572 WP_000381416.1 IS66 family transposase -
EKI55_RS20065 3926744..3927091 - 348 WP_000624618.1 IS66 family insertion sequence element accessory protein TnpB -
EKI55_RS20070 3927091..3927741 - 651 WP_000993931.1 IS66 family insertion sequence hypothetical protein -
EKI55_RS20075 3927906..3928127 + 222 WP_000692323.1 DUF987 domain-containing protein -
EKI55_RS20080 3928290..3928658 + 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EKI55_RS20085 3928748..3929125 + 378 WP_000854757.1 TA system toxin CbtA family protein Toxin
EKI55_RS20090 3929122..3929325 + 204 WP_000761705.1 hypothetical protein -
EKI55_RS20095 3929338..3929451 + 114 WP_001161660.1 DUF957 domain-containing protein -
EKI55_RS20100 3929610..3930638 + 1029 Protein_3835 IS110 family transposase -
EKI55_RS20110 3931092..3931274 + 183 WP_024167529.1 ethanolamine utilization protein -
EKI55_RS20115 3931375..3931704 - 330 WP_000450409.1 DUF496 family protein -
EKI55_RS20120 3931876..3932934 - 1059 WP_001200887.1 FUSC family protein -
EKI55_RS20125 3933132..3933605 - 474 WP_001105384.1 DNA gyrase inhibitor SbmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14153.18 Da        Isoelectric Point: 7.3249

>T120447 WP_000854757.1 NZ_CP037941:3928748-3929125 [Escherichia coli]
MKTLPDTHVREVSCCPSLVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQSGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T120447 NZ_CP037941:3928748-3929125 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCTCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAACAGCATATTG
AGGCAGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGTCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT120447 WP_001295723.1 NZ_CP037941:3928290-3928658 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT120447 NZ_CP037941:3928290-3928658 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A136X5A2

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References