Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143413..143918 Replicon chromosome
Accession NZ_CP037925
Organism Pseudomonas aeruginosa strain AES1M

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag CKAES1M_RS00650 Protein ID WP_003083773.1
Coordinates 143413..143694 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag CKAES1M_RS00655 Protein ID WP_003112628.1
Coordinates 143691..143918 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CKAES1M_RS00625 138664..140013 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
CKAES1M_RS00630 140062..140748 + 687 WP_003083762.1 FadR family transcriptional regulator -
CKAES1M_RS00635 140849..141583 + 735 WP_003115036.1 GntR family transcriptional regulator -
CKAES1M_RS00640 141787..142173 + 387 WP_014602345.1 aegerolysin family protein -
CKAES1M_RS00645 142205..143113 - 909 WP_003083769.1 LysR family transcriptional regulator -
CKAES1M_RS00650 143413..143694 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
CKAES1M_RS00655 143691..143918 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
CKAES1M_RS00660 144094..144714 - 621 WP_003101226.1 hypothetical protein -
CKAES1M_RS00665 144815..145315 + 501 WP_003101228.1 LEA type 2 family protein -
CKAES1M_RS00670 145388..145729 + 342 WP_003101229.1 alkylphosphonate utilization protein -
CKAES1M_RS00675 145811..147238 - 1428 WP_019681360.1 GABA permease -
CKAES1M_RS00680 147407..148900 - 1494 WP_019681361.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T120384 WP_003083773.1 NZ_CP037925:c143694-143413 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T120384 NZ_CP037925:c143694-143413 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGAGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT120384 WP_003112628.1 NZ_CP037925:c143918-143691 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT120384 NZ_CP037925:c143918-143691 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References