Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 2802164..2803008 Replicon chromosome
Accession NZ_CP037923
Organism Shigella flexneri 5a str. M90T

Toxin (Protein)


Gene name itaT Uniprot ID -
Locus tag EKN05_RS14565 Protein ID WP_014532172.1
Coordinates 2802547..2803008 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A4P7TQW7
Locus tag EKN05_RS14555 Protein ID WP_024260230.1
Coordinates 2802164..2802475 (+) Length 104 a.a.

Genomic Context

EKN05_RS14530EKN05_RS14535EKN05_RS14540EKN05_RS14545EKN05_RS14550EKN05_RS14555EKN05_RS14565EKN05_RS14585EKN05_RS14570EKN05_RS14575EKN05_RS14580
Location: 2797634..2798131 (498 bp)
Type: Others
Protein ID: Protein_2795
Location: 2798153..2800144 (1992 bp)
Type: Others
Protein ID: Protein_2796
Location: 2800134..2800748 (615 bp)
Type: Others
Protein ID: Protein_2797
Location: 2800748..2801077 (330 bp)
Type: Others
Protein ID: WP_000019869.1
Location: 2801089..2801979 (891 bp)
Type: Others
Protein ID: Protein_2799
Location: 2802164..2802475 (312 bp)
Type: Antitoxin
Protein ID: WP_024260230.1
Location: 2802547..2803008 (462 bp)
Type: Toxin
Protein ID: WP_014532172.1
Location: 2805904..2807274 (1371 bp)
Type: Others
Protein ID: WP_001000961.1
Location: 2803064..2803999 (936 bp)
Type: Others
Protein ID: WP_005105029.1
Location: 2804010..2804243 (234 bp)
Type: Others
Protein ID: WP_128600802.1
Location: 2804236..2805510 (1275 bp)
Type: Others
Protein ID: WP_005105027.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EKN05_RS14530 (EKN05_014545)2797634..2798131+498Protein_2795COX aromatic rich motif-containing protein-
EKN05_RS14535 (EKN05_014550)2798153..2800144+1992Protein_2796cytochrome o ubiquinol oxidase subunit I-
EKN05_RS14540 (EKN05_014555)2800134..2800748+615Protein_2797cytochrome o ubiquinol oxidase subunit III-
EKN05_RS14545 (EKN05_014560)2800748..2801077+330WP_000019869.1cytochrome o ubiquinol oxidase subunit IV-
EKN05_RS14550 (EKN05_014565)2801089..2801979+891Protein_2799heme o synthase-
EKN05_RS14555 (EKN05_014570)2802164..2802475+312WP_024260230.1DUF1778 domain-containing proteinAntitoxin
EKN05_RS14565 (EKN05_014580)2802547..2803008+462WP_014532172.1GNAT family N-acetyltransferaseToxin
EKN05_RS14570 (EKN05_014585)2803064..2803999-936WP_005105029.1tetratricopeptide repeat protein-
EKN05_RS14575 (EKN05_014590)2804010..2804243-234WP_128600802.1hypothetical protein-
EKN05_RS14580 (EKN05_014595)2804236..2805510-1275WP_005105027.1tetratricopeptide repeat protein-
EKN05_RS14585 (EKN05_014600)2805904..2807274+1371WP_001000961.1MFS transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-133)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 16623.52 Da        Isoelectric Point: 9.9538

>T120376 WP_014532172.1 NZ_CP037923:2802547-2803008 [Shigella flexneri 5a str. M90T]
MIAVTLLSINLYALRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGAR
KYQKRGFGQDLLCDFFEHVKKIHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 462 bp

>T120376 NZ_CP037923:2802547-2803008 [Shigella flexneri 5a str. M90T]
TTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACTG
TGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGCATATTCGCTGGAAAGAC
AACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGGAGCGCGG
AAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAAATTCACCCGGCATTACC
AATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCGA
CACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11440.14 Da        Isoelectric Point: 10.3388

>AT120376 WP_024260230.1 NZ_CP037923:2802164-2802475 [Shigella flexneri 5a str. M90T]
MLGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIT
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT120376 NZ_CP037923:2802164-2802475 [Shigella flexneri 5a str. M90T]
ATGCTTGGAAAAACAGCCGCTCTATACGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCACT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A4P7TQW7

References