Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 2764543..2765161 | Replicon | chromosome |
| Accession | NZ_CP037923 | ||
| Organism | Shigella flexneri 5a str. M90T | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | H5UYE2 |
| Locus tag | EKN05_RS14370 | Protein ID | WP_001291435.1 |
| Coordinates | 2764943..2765161 (+) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | Q0T7C3 |
| Locus tag | EKN05_RS14365 | Protein ID | WP_000344797.1 |
| Coordinates | 2764543..2764917 (+) | Length | 125 a.a. |
Genomic Context
Location: 2759632..2760825 (1194 bp)
Type: Others
Protein ID: WP_024260231.1
Type: Others
Protein ID: WP_024260231.1
Location: 2760848..2763997 (3150 bp)
Type: Others
Protein ID: WP_001132471.1
Type: Others
Protein ID: WP_001132471.1
Location: 2764543..2764917 (375 bp)
Type: Antitoxin
Protein ID: WP_000344797.1
Type: Antitoxin
Protein ID: WP_000344797.1
Location: 2764943..2765161 (219 bp)
Type: Toxin
Protein ID: WP_001291435.1
Type: Toxin
Protein ID: WP_001291435.1
Location: 2765333..2765884 (552 bp)
Type: Others
Protein ID: WP_000102569.1
Type: Others
Protein ID: WP_000102569.1
Location: 2766000..2766470 (471 bp)
Type: Others
Protein ID: WP_000136192.1
Type: Others
Protein ID: WP_000136192.1
Location: 2766634..2768184 (1551 bp)
Type: Others
Protein ID: WP_005066536.1
Type: Others
Protein ID: WP_005066536.1
Location: 2768958..2769269 (312 bp)
Type: Others
Protein ID: WP_000409911.1
Type: Others
Protein ID: WP_000409911.1
Location: 2768226..2768579 (354 bp)
Type: Others
Protein ID: WP_000878140.1
Type: Others
Protein ID: WP_000878140.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EKN05_RS14355 (EKN05_014365) | 2759632..2760825 | + | 1194 | WP_024260231.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
| EKN05_RS14360 (EKN05_014370) | 2760848..2763997 | + | 3150 | WP_001132471.1 | efflux RND transporter permease AcrB | - |
| EKN05_RS14365 (EKN05_014375) | 2764543..2764917 | + | 375 | WP_000344797.1 | Hha toxicity modulator TomB | Antitoxin |
| EKN05_RS14370 (EKN05_014380) | 2764943..2765161 | + | 219 | WP_001291435.1 | HHA domain-containing protein | Toxin |
| EKN05_RS14375 (EKN05_014385) | 2765333..2765884 | + | 552 | WP_000102569.1 | maltose O-acetyltransferase | - |
| EKN05_RS14380 (EKN05_014390) | 2766000..2766470 | + | 471 | WP_000136192.1 | YlaC family protein | - |
| EKN05_RS14385 (EKN05_014395) | 2766634..2768184 | + | 1551 | WP_005066536.1 | cyclic-guanylate-specific phosphodiesterase PdeB | - |
| EKN05_RS14390 (EKN05_014400) | 2768226..2768579 | - | 354 | WP_000878140.1 | DUF1428 domain-containing protein | - |
| EKN05_RS14400 (EKN05_014410) | 2768958..2769269 | + | 312 | WP_000409911.1 | MGMT family protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T120375 WP_001291435.1 NZ_CP037923:2764943-2765161 [Shigella flexneri 5a str. M90T]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR
Download Length: 219 bp
>T120375 NZ_CP037923:2764943-2765161 [Shigella flexneri 5a str. M90T]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14513.38 Da Isoelectric Point: 4.9091
>AT120375 WP_000344797.1 NZ_CP037923:2764543-2764917 [Shigella flexneri 5a str. M90T]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC
Download Length: 375 bp
>AT120375 NZ_CP037923:2764543-2764917 [Shigella flexneri 5a str. M90T]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG