Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3763901..3764558 Replicon chromosome
Accession NZ_CP037919
Organism Enterobacter cloacae complex sp. strain N13-01531

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag E2E36_RS17905 Protein ID WP_021242050.1
Coordinates 3763901..3764311 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag E2E36_RS17910 Protein ID WP_006178375.1
Coordinates 3764292..3764558 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2E36_RS17885 3759894..3761627 - 1734 WP_133295108.1 single-stranded-DNA-specific exonuclease RecJ -
E2E36_RS17890 3761633..3762346 - 714 WP_029740340.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
E2E36_RS17895 3762375..3763271 - 897 WP_133295109.1 site-specific tyrosine recombinase XerD -
E2E36_RS17900 3763373..3763894 + 522 WP_008499710.1 flavodoxin FldB -
E2E36_RS17905 3763901..3764311 - 411 WP_021242050.1 protein YgfX Toxin
E2E36_RS17910 3764292..3764558 - 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
E2E36_RS17915 3764853..3765833 + 981 WP_133295110.1 tRNA-modifying protein YgfZ -
E2E36_RS17920 3765944..3766603 - 660 WP_127732244.1 hemolysin III family protein -
E2E36_RS17925 3766769..3767080 - 312 WP_133295111.1 N(4)-acetylcytidine aminohydrolase -
E2E36_RS17930 3767132..3767863 + 732 WP_032660101.1 MurR/RpiR family transcriptional regulator -
E2E36_RS17935 3767980..3769413 + 1434 WP_115876233.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T120357 WP_021242050.1 NZ_CP037919:c3764311-3763901 [Enterobacter cloacae complex sp.]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

>T120357 NZ_CP037919:c3764311-3763901 [Enterobacter cloacae complex sp.]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGACTGGTTGCGGC
CTTTGTGTTACTGATGCCGTGGCCGCTAAGCTATACGCCGCTGTGGCTGCTGTTACTCTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGAATTAATGCCCGTCAGGGAGAGATCAAATTACTGATGGATTCCCGCCTGCGCTGGCAGGGTAAA
GAGTGGGATATCCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGTTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTTTGGCTGGCGGCTGACAGTATGGATGCTGCCGAGTGGCGAGATCTGCGCCGGATGCTATTGCAACAGACGA
CGCAGGGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT120357 WP_006178375.1 NZ_CP037919:c3764558-3764292 [Enterobacter cloacae complex sp.]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT120357 NZ_CP037919:c3764558-3764292 [Enterobacter cloacae complex sp.]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGAATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGATGATAAGCGTCTGTTTGTTCGCCTGCTTGAGTCTGACGATCCAGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGATACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References