Detailed information of TA system TA120345

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 1625769..1626309
• Replicon: chromosome
• Accession: NZ_CP037913
• Organism: Sphingomonas sp. AAP5

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E2E30_RS07400
• Protein ID: WP_133191970.1
• Coordinates: 1625769..1626059 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: E2E30_RS07405
• Protein ID: WP_133188648.1
• Coordinates: 1626049..1626309 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E2E30_RS07380	1623095..1623412	-	318	WP_133191968.1	FYDLN acid domain-containing protein	-
E2E30_RS07385	1623551..1624900	+	1350	WP_133188644.1	3-phosphoshikimate 1-carboxyvinyltransferase	-
E2E30_RS07390	1624897..1625145	+	249	WP_206365655.1	hypothetical protein	-
E2E30_RS07395	1625142..1625768	+	627	WP_133188646.1	(d)CMP kinase	-
E2E30_RS07400	1625769..1626059	-	291	WP_133191970.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E2E30_RS07405	1626049..1626309	-	261	WP_133188648.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
E2E30_RS07410	1626598..1628331	+	1734	WP_133188650.1	30S ribosomal protein S1	-
E2E30_RS07415	1628490..1628768	+	279	WP_133188652.1	integration host factor subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

• Antitoxin ParD (3-70)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11034.58 Da
• Isoelectric Point: 8.4641

>T120345 WP_133191970.1 NZ_CP037913:c1626059-1625769 [Sphingomonas sp. AAP5]
MPYRLSQPARRDLDEIYIRGAELFGIAQADEYSAGMAQTLTFLASYPRAARERTEIVPPVRAHRYKAHVVIYRLAEDGIL
ILRVRHGHEDWTSNPV

Nucleotide

• Length: 291 bp

>T120345 NZ_CP037913:c1626059-1625769 [Sphingomonas sp. AAP5]
ATGCCCTATAGGCTCTCGCAGCCAGCGAGGCGTGACCTCGACGAAATCTACATCCGGGGGGCGGAGCTATTCGGCATAGC
CCAGGCCGACGAATACAGCGCTGGCATGGCGCAGACGCTCACGTTTTTGGCATCCTATCCGCGCGCAGCGCGGGAGCGAA
CCGAGATCGTGCCGCCGGTGCGTGCGCATCGGTACAAGGCGCATGTCGTGATCTATCGTTTGGCGGAAGATGGGATCCTG
ATCTTGCGGGTCCGTCACGGGCACGAAGATTGGACGTCCAACCCAGTATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9557.75 Da
• Isoelectric Point: 4.4746

>AT120345 WP_133188648.1 NZ_CP037913:c1626309-1626049 [Sphingomonas sp. AAP5]
MATMNISLPDAMKDWVEAQAATGRFGNSSDVVRDLIRREQVRVDKIANMQRMVDEALEGGVSDLTAEDVFAEARRRFLAR
DGSDAL

Nucleotide

• Length: 261 bp

>AT120345 NZ_CP037913:c1626309-1626049 [Sphingomonas sp. AAP5]
ATGGCCACGATGAACATTTCCCTGCCCGATGCGATGAAGGATTGGGTAGAGGCGCAGGCCGCGACAGGCCGCTTCGGCAA
CAGCAGCGATGTCGTCCGCGACCTGATCCGGCGGGAGCAGGTTCGGGTGGATAAGATCGCCAACATGCAGAGGATGGTCG
ACGAAGCCCTGGAAGGTGGAGTCTCCGACCTGACAGCGGAAGACGTGTTTGCTGAAGCTCGCCGGCGTTTCCTCGCGCGT
GACGGTAGCGATGCCCTATAG