Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 468685..469302 Replicon chromosome
Accession NZ_CP037913
Organism Sphingomonas sp. AAP5

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E2E30_RS02160 Protein ID WP_206365625.1
Coordinates 468685..468876 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E2E30_RS02165 Protein ID WP_133186821.1
Coordinates 468886..469302 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2E30_RS02130 464114..464488 + 375 WP_133186809.1 hypothetical protein -
E2E30_RS02135 464485..465234 + 750 WP_133186811.1 SufD family Fe-S cluster assembly protein -
E2E30_RS02140 465272..466486 + 1215 WP_133186813.1 cysteine desulfurase -
E2E30_RS02145 466483..466944 + 462 WP_133186815.1 SUF system Fe-S cluster assembly protein -
E2E30_RS02150 467069..467422 + 354 WP_133186817.1 iron-sulfur cluster assembly accessory protein -
E2E30_RS02155 467467..468648 + 1182 WP_133186819.1 NAD(P)/FAD-dependent oxidoreductase -
E2E30_RS02160 468685..468876 + 192 WP_206365625.1 type II toxin-antitoxin system HicA family toxin Toxin
E2E30_RS02165 468886..469302 + 417 WP_133186821.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E2E30_RS02170 469314..469550 + 237 WP_133186823.1 hypothetical protein -
E2E30_RS02175 469641..471356 + 1716 WP_133186825.1 DEAD/DEAH box helicase -
E2E30_RS02180 471428..472522 + 1095 WP_133186827.1 histidinol-phosphate transaminase -
E2E30_RS02185 472525..473223 + 699 WP_206365679.1 haloacid dehalogenase type II -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(8-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-125)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 6999.25 Da        Isoelectric Point: 11.6952

>T120343 WP_206365625.1 NZ_CP037913:468685-468876 [Sphingomonas sp. AAP5]
MMRTMKSADLIRELKSAGWTLDRVRGSHHVFTHPQHGGHIVVPHPKKDLGPGLVAAIRKQAKV

Download         Length: 192 bp

>T120343 NZ_CP037913:468685-468876 [Sphingomonas sp. AAP5]
ATGATGCGCACGATGAAAAGCGCCGATCTCATTCGTGAGTTGAAATCGGCCGGGTGGACACTCGATCGGGTGCGGGGATC
GCACCACGTTTTCACCCATCCACAGCACGGCGGGCATATCGTCGTGCCGCATCCCAAGAAGGATCTCGGGCCGGGGCTGG
TCGCTGCGATCCGCAAGCAGGCAAAGGTCTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14396.20 Da        Isoelectric Point: 4.0703

>AT120343 WP_133186821.1 NZ_CP037913:468886-469302 [Sphingomonas sp. AAP5]
MRYPIAIEPGSNSTAFGVVVPDLPGCFSAGDTLDDALVGAEEAAAAWIDAALDAGTAIPPARSLDTLRLDPDFDGWAFGV
ISLDPALLEDTIERVNVTLPRRVLKRLDAMARAAGQSRSSYIASLTLDSPAPSGERAA

Download         Length: 417 bp

>AT120343 NZ_CP037913:468886-469302 [Sphingomonas sp. AAP5]
ATGCGGTATCCCATCGCCATCGAACCTGGTAGCAACAGCACTGCCTTCGGCGTCGTGGTGCCCGATCTGCCGGGGTGCTT
TTCCGCGGGTGATACGCTCGACGACGCGCTCGTCGGCGCCGAGGAAGCCGCAGCGGCGTGGATCGATGCTGCGCTCGACG
CGGGCACGGCAATTCCGCCGGCGCGAAGCCTCGATACGCTGCGGCTGGATCCGGACTTTGATGGCTGGGCGTTCGGCGTG
ATCTCGCTCGACCCCGCGCTTCTCGAAGACACGATCGAGCGGGTCAACGTAACCCTGCCAAGGCGAGTCCTGAAGCGCCT
CGACGCGATGGCACGCGCTGCGGGGCAGAGCCGGTCGAGCTATATCGCTTCGCTGACGCTCGACTCGCCGGCGCCGTCGG
GCGAGCGAGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References