Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1464..2085 Replicon chromosome
Accession NZ_CP037913
Organism Sphingomonas sp. AAP5

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E2E30_RS00015 Protein ID WP_133186072.1
Coordinates 1684..2085 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E2E30_RS00010 Protein ID WP_133186070.1
Coordinates 1464..1694 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E2E30_RS00005 13..1413 + 1401 WP_133186068.1 chromosomal replication initiator protein DnaA -
E2E30_RS00010 1464..1694 + 231 WP_133186070.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E2E30_RS00015 1684..2085 + 402 WP_133186072.1 PIN domain-containing protein Toxin
E2E30_RS00020 2082..3083 - 1002 WP_133186074.1 tryptophan--tRNA ligase -
E2E30_RS00025 3087..4679 - 1593 WP_133186076.1 murein biosynthesis integral membrane protein MurJ -
E2E30_RS00030 4809..5321 - 513 WP_133186078.1 protein-export chaperone SecB -
E2E30_RS00035 5512..6156 + 645 WP_133186080.1 Tim44/TimA family putative adaptor protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-114)

Antitoxin

SpoVT-AbrB domain

(5-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14549.85 Da        Isoelectric Point: 5.6310

>T120342 WP_133186072.1 NZ_CP037913:1684-2085 [Sphingomonas sp. AAP5]
MPGSFFDSNVPLYLAAGTSPKADRAESLLSKGGVISVQVLNEIANVGLRKFGMSMAQLDLFLAGIRGAMRTIPVSIEIHE
LALEVRERHRFAFYDCAIVAAALLADCDTLWSEDMHDGLVIDRRLTIRNPFAA

Download         Length: 402 bp

>T120342 NZ_CP037913:1684-2085 [Sphingomonas sp. AAP5]
ATGCCCGGTAGCTTTTTCGACAGCAACGTTCCGCTCTATCTCGCTGCGGGCACGTCGCCAAAAGCCGATCGCGCCGAGTC
GCTCCTGTCGAAAGGTGGTGTGATCAGCGTTCAGGTCCTGAACGAGATCGCCAATGTCGGGCTCCGCAAGTTCGGGATGT
CGATGGCCCAACTCGACCTATTCCTAGCCGGGATTCGCGGCGCGATGCGAACGATCCCGGTTTCGATCGAGATTCACGAA
TTGGCGCTGGAAGTCCGCGAACGGCACCGTTTTGCGTTTTACGACTGCGCGATCGTCGCCGCGGCGCTGCTCGCCGACTG
CGATACCCTGTGGTCCGAAGACATGCACGACGGCCTCGTCATCGACCGCCGCTTGACGATCCGCAACCCGTTCGCCGCTT
AG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8709.05 Da        Isoelectric Point: 4.6310

>AT120342 WP_133186070.1 NZ_CP037913:1464-1694 [Sphingomonas sp. AAP5]
MQLAKWGDDFAVRLPKEMVEALAVELGEELDVRVQLDGSIRISRKMTPEEAIIGLRQFRGMMPADFKFDRDEANAR

Download         Length: 231 bp

>AT120342 NZ_CP037913:1464-1694 [Sphingomonas sp. AAP5]
ATGCAGTTGGCGAAGTGGGGCGACGACTTCGCGGTCCGTTTGCCCAAGGAAATGGTCGAGGCGCTCGCGGTAGAGCTTGG
CGAGGAGCTCGATGTGCGGGTTCAGCTAGACGGGTCGATCCGCATTTCGCGCAAGATGACGCCCGAAGAGGCGATCATAG
GTCTGCGGCAGTTTCGGGGGATGATGCCCGCGGACTTCAAGTTCGACCGTGACGAAGCGAATGCCCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References