Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2411237..2411875 Replicon chromosome
Accession NZ_CP037910
Organism Escherichia coli strain YSP8-1

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag E1J56_RS11705 Protein ID WP_000813794.1
Coordinates 2411699..2411875 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E1J56_RS11700 Protein ID WP_001270286.1
Coordinates 2411237..2411653 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1J56_RS11680 2406389..2407330 - 942 WP_001251313.1 ABC transporter permease -
E1J56_RS11685 2407331..2408344 - 1014 WP_000220399.1 ABC transporter ATP-binding protein -
E1J56_RS11690 2408362..2409507 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
E1J56_RS11695 2409752..2411158 - 1407 WP_136655426.1 PLP-dependent aminotransferase family protein -
E1J56_RS11700 2411237..2411653 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
E1J56_RS11705 2411699..2411875 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
E1J56_RS11710 2412097..2412327 + 231 WP_000494244.1 YncJ family protein -
E1J56_RS11715 2412419..2414380 - 1962 WP_001752477.1 23S rRNA 5-hydroxycytidine C2501 synthase -
E1J56_RS11720 2414453..2414989 - 537 WP_000429141.1 DNA-binding transcriptional regulator SutR -
E1J56_RS11725 2415042..2416271 + 1230 WP_096218838.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2416311..2417459 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T120327 WP_000813794.1 NZ_CP037910:c2411875-2411699 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T120327 NZ_CP037910:c2411875-2411699 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT120327 WP_001270286.1 NZ_CP037910:c2411653-2411237 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT120327 NZ_CP037910:c2411653-2411237 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References