Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3726528..3727362 Replicon chromosome
Accession NZ_CP037903
Organism Escherichia coli strain LHM10-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2X7CAN1
Locus tag E1J55_RS18100 Protein ID WP_039025883.1
Coordinates 3726528..3726905 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2X5LBZ2
Locus tag E1J55_RS18105 Protein ID WP_039025882.1
Coordinates 3726994..3727362 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1J55_RS18065 3721957..3722178 + 222 WP_000691994.1 DUF987 domain-containing protein -
E1J55_RS18070 3722197..3722514 + 318 WP_000070396.1 type IV toxin-antitoxin system antitoxin YafW -
E1J55_RS18075 3722535..3722876 + 342 WP_000854680.1 type IV toxin-antitoxin system toxin YkfI -
E1J55_RS18080 3723469..3724788 + 1320 WP_105284452.1 site-specific integrase -
E1J55_RS18085 3724881..3725729 - 849 WP_039025884.1 DUF4942 domain-containing protein -
E1J55_RS18090 3725826..3726023 - 198 WP_000772024.1 DUF957 domain-containing protein -
E1J55_RS18095 3726043..3726531 - 489 Protein_3511 hypothetical protein -
E1J55_RS18100 3726528..3726905 - 378 WP_039025883.1 type IV toxin-antitoxin system toxin CbtA Toxin
E1J55_RS18105 3726994..3727362 - 369 WP_039025882.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
E1J55_RS18110 3727412..3728056 - 645 WP_136698443.1 antitoxin of toxin-antitoxin stability system -
E1J55_RS18115 3728071..3728292 - 222 WP_000692312.1 DUF987 domain-containing protein -
E1J55_RS18120 3728361..3728837 - 477 WP_001186745.1 RadC family protein -
E1J55_RS18125 3728852..3729337 - 486 WP_000214316.1 antirestriction protein -
E1J55_RS18130 3729428..3730246 - 819 WP_001234702.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14176.22 Da        Isoelectric Point: 7.8523

>T120292 WP_039025883.1 NZ_CP037903:c3726905-3726528 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQLEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T120292 NZ_CP037903:c3726905-3726528 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCTGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGAGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13792.52 Da        Isoelectric Point: 5.9582

>AT120292 WP_039025882.1 NZ_CP037903:c3727362-3726994 [Escherichia coli]
VSDTFHETNYPDNNNDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT120292 NZ_CP037903:c3727362-3726994 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACAACAACAACGATCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X7CAN1

Antitoxin

Source ID Structure
AlphaFold DB A0A2X5LBZ2

References