Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yafW-ykfI/CbtA-CbeA |
| Location | 3722197..3722876 | Replicon | chromosome |
| Accession | NZ_CP037903 | ||
| Organism | Escherichia coli strain LHM10-1 | ||
Toxin (Protein)
| Gene name | ykfI | Uniprot ID | S1FHS4 |
| Locus tag | E1J55_RS18075 | Protein ID | WP_000854680.1 |
| Coordinates | 3722535..3722876 (+) | Length | 114 a.a. |
Antitoxin (Protein)
| Gene name | yafW | Uniprot ID | S1EWR7 |
| Locus tag | E1J55_RS18070 | Protein ID | WP_000070396.1 |
| Coordinates | 3722197..3722514 (+) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E1J55_RS18025 | 3717634..3718455 | + | 822 | WP_136698440.1 | DUF945 domain-containing protein | - |
| E1J55_RS18030 | 3718672..3719373 | + | 702 | WP_136698441.1 | WYL domain-containing protein | - |
| E1J55_RS18035 | 3719414..3719650 | + | 237 | WP_001144031.1 | hypothetical protein | - |
| E1J55_RS18040 | 3719650..3720093 | + | 444 | WP_029039038.1 | hypothetical protein | - |
| E1J55_RS18045 | 3720117..3720584 | + | 468 | WP_136698442.1 | hypothetical protein | - |
| E1J55_RS18050 | 3720661..3720900 | + | 240 | WP_000194654.1 | DUF905 domain-containing protein | - |
| E1J55_RS18055 | 3720998..3721456 | + | 459 | WP_000211838.1 | antirestriction protein | - |
| E1J55_RS18060 | 3721472..3721948 | + | 477 | WP_000811693.1 | RadC family protein | - |
| E1J55_RS18065 | 3721957..3722178 | + | 222 | WP_000691994.1 | DUF987 domain-containing protein | - |
| E1J55_RS18070 | 3722197..3722514 | + | 318 | WP_000070396.1 | type IV toxin-antitoxin system antitoxin YafW | Antitoxin |
| E1J55_RS18075 | 3722535..3722876 | + | 342 | WP_000854680.1 | type IV toxin-antitoxin system toxin YkfI | Toxin |
| E1J55_RS18080 | 3723469..3724788 | + | 1320 | WP_105284452.1 | site-specific integrase | - |
| E1J55_RS18085 | 3724881..3725729 | - | 849 | WP_039025884.1 | DUF4942 domain-containing protein | - |
| E1J55_RS18090 | 3725826..3726023 | - | 198 | WP_000772024.1 | DUF957 domain-containing protein | - |
| E1J55_RS18095 | 3726043..3726531 | - | 489 | Protein_3511 | hypothetical protein | - |
| E1J55_RS18100 | 3726528..3726905 | - | 378 | WP_039025883.1 | type IV toxin-antitoxin system toxin CbtA | - |
| E1J55_RS18105 | 3726994..3727362 | - | 369 | WP_039025882.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 12892.95 Da Isoelectric Point: 9.6543
>T120291 WP_000854680.1 NZ_CP037903:3722535-3722876 [Escherichia coli]
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
MKTLPATTQRAVKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR
Download Length: 342 bp
>T120291 NZ_CP037903:3722535-3722876 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11982.62 Da Isoelectric Point: 7.0270
>AT120291 WP_000070396.1 NZ_CP037903:3722197-3722514 [Escherichia coli]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTLGSCGYVYIAIYPTQR
Download Length: 318 bp
>AT120291 NZ_CP037903:3722197-3722514 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|