Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3507427..3508045 Replicon chromosome
Accession NZ_CP037903
Organism Escherichia coli strain LHM10-1

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag E1J55_RS17040 Protein ID WP_001291435.1
Coordinates 3507827..3508045 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag E1J55_RS17035 Protein ID WP_089601776.1
Coordinates 3507427..3507801 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1J55_RS17025 3502955..3506104 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
E1J55_RS17030 3506288..3506985 - 698 Protein_3302 IS1 family transposase -
E1J55_RS17035 3507427..3507801 + 375 WP_089601776.1 Hha toxicity modulator TomB Antitoxin
E1J55_RS17040 3507827..3508045 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
E1J55_RS17045 3508217..3508768 + 552 WP_000102564.1 maltose O-acetyltransferase -
E1J55_RS17050 3508884..3509354 + 471 WP_000136192.1 YlaC family protein -
E1J55_RS17055 3509518..3511068 + 1551 WP_001469946.1 cyclic-guanylate-specific phosphodiesterase PdeB -
E1J55_RS17060 3511110..3511463 - 354 Protein_3308 DUF1428 family protein -
E1J55_RS17070 3511842..3512153 + 312 WP_000409911.1 MGMT family protein -
E1J55_RS17075 3512184..3512756 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T120289 WP_001291435.1 NZ_CP037903:3507827-3508045 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T120289 NZ_CP037903:3507827-3508045 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14587.42 Da        Isoelectric Point: 4.7395

>AT120289 WP_089601776.1 NZ_CP037903:3507427-3507801 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSSNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT120289 NZ_CP037903:3507427-3507801 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAAGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure

References