Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1175251..1175864 Replicon chromosome
Accession NZ_CP037900
Organism Cupriavidus metallidurans strain BS1

Toxin (Protein)


Gene name hicA Uniprot ID Q1LPG3
Locus tag DDF84_RS05480 Protein ID WP_011515865.1
Coordinates 1175685..1175864 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A482IMU2
Locus tag DDF84_RS05475 Protein ID WP_024569172.1
Coordinates 1175251..1175655 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDF84_RS05460 1170641..1171174 + 534 WP_017514429.1 peptidylprolyl isomerase -
DDF84_RS05465 1171269..1172321 - 1053 WP_024569170.1 hypothetical protein -
DDF84_RS05470 1172318..1174924 - 2607 WP_035834685.1 DNA mismatch repair protein MutS -
DDF84_RS05475 1175251..1175655 - 405 WP_024569172.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DDF84_RS05480 1175685..1175864 - 180 WP_011515865.1 type II toxin-antitoxin system HicA family toxin Toxin
DDF84_RS05485 1176068..1176889 - 822 WP_017513083.1 inositol monophosphatase -
DDF84_RS05490 1177117..1177986 + 870 WP_017513082.1 RNA methyltransferase -
DDF84_RS05495 1178315..1179058 + 744 WP_017513081.1 serine O-acetyltransferase -
DDF84_RS05500 1179107..1179898 - 792 WP_017513080.1 UDP-2,3-diacylglucosamine diphosphatase -
DDF84_RS05505 1179967..1180467 - 501 WP_011515870.1 peptidyl-prolyl cis-trans isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6790.07 Da        Isoelectric Point: 12.3707

>T120271 WP_011515865.1 NZ_CP037900:c1175864-1175685 [Cupriavidus metallidurans]
MHSSTLIRLLEQKGWKLVRTHGSHFTFKHPRHMLIVTVPHPKKDLPTGTVRNILRTAGL

Download         Length: 180 bp

>T120271 NZ_CP037900:c1175864-1175685 [Cupriavidus metallidurans]
TTGCATTCGTCCACGCTGATCCGATTGCTCGAACAGAAGGGGTGGAAGCTGGTGCGCACGCATGGCAGTCATTTCACCTT
CAAACATCCGCGGCACATGCTGATTGTGACCGTGCCCCATCCAAAGAAGGATCTGCCGACAGGCACGGTCCGAAACATTC
TGAGGACGGCCGGGCTATGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14500.64 Da        Isoelectric Point: 5.1814

>AT120271 WP_024569172.1 NZ_CP037900:c1175655-1175251 [Cupriavidus metallidurans]
MDFPIAIHKDANSVYGVTVPDVAGCYSAGESIEEAVRNAREAITTHVVALLSLGEEVVLKATPIGTLMAQPEYAGAIWAL
ADIDMSKLDARPERINISLPRFVLHKIDTFVERRHETRSGFLARVALDAIAGSV

Download         Length: 405 bp

>AT120271 NZ_CP037900:c1175655-1175251 [Cupriavidus metallidurans]
ATGGACTTTCCCATTGCCATTCACAAGGATGCGAACTCGGTCTACGGCGTGACGGTGCCCGATGTGGCGGGCTGTTACTC
CGCCGGCGAATCCATCGAGGAAGCGGTCCGCAACGCACGCGAGGCCATCACGACTCACGTGGTGGCCCTGCTCTCCCTTG
GCGAGGAGGTTGTTCTGAAAGCGACGCCGATCGGCACGCTGATGGCCCAACCGGAGTACGCAGGCGCGATCTGGGCGCTG
GCCGACATCGACATGAGCAAGCTCGACGCACGCCCGGAGCGAATCAATATCAGCCTGCCTCGTTTTGTATTGCACAAGAT
CGACACGTTCGTGGAACGTCGCCACGAAACCCGGAGCGGGTTCCTCGCGCGCGTCGCGCTGGACGCCATCGCGGGCAGCG
TCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0WZI7

Antitoxin

Source ID Structure
AlphaFold DB A0A482IMU2

References