Detailed information of TA system TA120270

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 74444..74969
• Replicon: plasmid PNCS015054 strain 4[5]12:i:-
• Accession: NZ_CP037876
• Organism: Salmonella enterica subsp. enterica serovar 4[5]12:i:- strain PNCS015054

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: I3W3D5
• Locus tag: E1966_RS01775
• Protein ID: WP_001159863.1
• Coordinates: 74444..74749 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: M7S5D0
• Locus tag: E1966_RS01780
• Protein ID: WP_000813641.1
• Coordinates: 74751..74969 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1966_RS01740	69823..70383	-	561	WP_000900095.1	inverse autotransporter beta domain-containing protein	-
E1966_RS25070	70539..70826	+	288	WP_071530243.1	hypothetical protein	-
E1966_RS01745	71103..71588	-	486	WP_000905606.1	membrane protein	-
E1966_RS01750	71582..72091	-	510	WP_001541544.1	CaiF/GrlA family transcriptional regulator	-
E1966_RS01755	72095..72808	-	714	Protein_85	EAL domain-containing protein	-
E1966_RS01760	72817..73599	-	783	WP_000082169.1	site-specific integrase	-
E1966_RS01765	73634..74155	-	522	WP_000198608.1	hypothetical protein	-
E1966_RS01770	74152..74442	-	291	WP_001266176.1	hypothetical protein	-
E1966_RS01775	74444..74749	-	306	WP_001159863.1	type II toxin-antitoxin system toxin CcdB	Toxin
E1966_RS01780	74751..74969	-	219	WP_000813641.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
E1966_RS01785	75645..76166	+	522	WP_010999942.1	hypothetical protein	-
E1966_RS01790	76650..76946	+	297	WP_001687482.1	hypothetical protein	-
E1966_RS01795	77440..78429	+	990	WP_001527061.1	RepB family plasmid replication initiator protein	-
E1966_RS01800	78688..79132	-	445	Protein_94	site-specific integrase	-
E1966_RS01805	79301..79682	-	382	Protein_95	YgiW/YdeI family stress tolerance OB fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..96545	96545

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Antitoxin ParD (1-58)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 15030.03 Da
• Isoelectric Point: 5.5500

>T120270 WP_001159863.1 NZ_CP037876:c74749-74444 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 306 bp

>T120270 NZ_CP037876:c74749-74444 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
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Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 10761.91 Da
• Isoelectric Point: 5.5500

>AT120270 WP_000813641.1 NZ_CP037876:c74969-74751 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 219 bp

>AT120270 NZ_CP037876:c74969-74751 [Salmonella enterica subsp. enterica serovar 4,[5],12:i:-]
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Structures

Toxin

• AlphaFold DB: I3W3D5

Antitoxin

• AlphaFold DB: A0A656ICA6