Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3267506..3269060 Replicon chromosome
Accession NZ_CP037867
Organism Hydrogenophaga pseudoflava strain DSM 1084

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag HPF_RS15675 Protein ID WP_133157107.1
Coordinates 3267506..3268822 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag HPF_RS15680 Protein ID WP_133157108.1
Coordinates 3268824..3269060 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPF_RS15645 3262884..3264437 - 1554 WP_133158130.1 IS66 family transposase -
HPF_RS15650 3264518..3264850 - 333 WP_133157105.1 IS66 family insertion sequence element accessory protein TnpB -
HPF_RS15655 3264847..3265239 - 393 WP_079365167.1 IS66 family insertion sequence hypothetical protein -
HPF_RS15660 3265316..3265765 - 450 Protein_3099 IS21 family transposase -
HPF_RS15665 3265875..3266174 - 300 WP_079365169.1 hypothetical protein -
HPF_RS15670 3266815..3267417 - 603 WP_165961718.1 HipA domain-containing protein -
HPF_RS15675 3267506..3268822 - 1317 WP_133157107.1 type II toxin-antitoxin system HipA family toxin Toxin
HPF_RS15680 3268824..3269060 - 237 WP_133157108.1 helix-turn-helix transcriptional regulator Antitoxin
HPF_RS15685 3269336..3270427 - 1092 WP_133157109.1 HipA domain-containing protein -
HPF_RS15690 3270446..3270694 - 249 WP_133157110.1 hypothetical protein -
HPF_RS15695 3270691..3271014 - 324 WP_133157111.1 helix-turn-helix transcriptional regulator -
HPF_RS15700 3271519..3272157 - 639 WP_133157112.1 3-oxoacid CoA-transferase subunit B -
HPF_RS15705 3272169..3272870 - 702 WP_133157113.1 3-oxoacid CoA-transferase subunit A -
HPF_RS15710 3272898..3273908 - 1011 WP_133157114.1 NAD(P)H-quinone oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-63)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 47540.33 Da        Isoelectric Point: 7.0087

>T120266 WP_133157107.1 NZ_CP037867:c3268822-3267506 [Hydrogenophaga pseudoflava]
MVRQLDVWLTGAHPGTLIGTLTQSEGRLAFRYRPEWLASGHATPLSQSLPLQADEFDDRATRPFFAGLLPEGDKRRLVAQ
ALGVSRQNDFALLDGIGGECAGAVTLLEPGQAPVDAAVPNAVRWLDDADLLKLLGDMPRRPMLAGDGDLRLSLAGAQDKL
PVVVQGDRIGLPLFGSPSTHILKPTIQGIEGSVYNEGFCMALARAIGLDAAPTEIRRVQDQPFLLVQRYDRLAVQPSNAQ
QTPAATQRLHQEDFCQALGVPPELKYQNEGGPDLTQAFALVRSATRPSAPQLIKLLDFVLFNALIGNHDAHAKNFSLLYT
PLGAVLAPMYDALCTAAYPDLSDRMAMKIGSKYRFTDLYPRHWAQFASEAGLSPAQVKKALKRAAERLPERAHQTQAQLA
GQGHQHAVIAQIGKLIEDRCATTLRRLAMPSTATDSDS

Download         Length: 1317 bp

>T120266 NZ_CP037867:c3268822-3267506 [Hydrogenophaga pseudoflava]
ATGGTCCGTCAACTCGATGTCTGGCTGACAGGCGCTCACCCGGGCACCCTCATCGGCACCCTCACACAGTCCGAAGGCCG
CCTCGCGTTCCGCTACCGGCCCGAATGGCTGGCCAGCGGCCACGCCACGCCCCTGTCCCAATCGCTGCCGCTGCAGGCGG
ACGAATTCGACGACCGCGCCACGCGCCCTTTCTTCGCAGGCCTGCTGCCCGAGGGCGACAAGCGCCGGCTCGTGGCGCAG
GCACTGGGCGTCTCCCGTCAGAATGACTTTGCCCTGCTCGACGGCATCGGCGGTGAATGTGCGGGCGCTGTCACCCTGCT
GGAGCCCGGGCAGGCGCCCGTCGACGCTGCGGTTCCCAACGCTGTGCGTTGGCTGGACGATGCCGACCTGCTCAAGCTGC
TGGGCGACATGCCGCGCAGGCCCATGCTGGCGGGCGACGGCGACCTGCGCCTGTCGCTGGCGGGTGCGCAAGACAAGCTG
CCCGTGGTGGTGCAGGGCGACCGCATCGGCCTGCCCTTGTTCGGTTCTCCCAGCACCCACATCCTCAAGCCGACCATTCA
GGGCATCGAGGGCAGCGTCTACAACGAGGGCTTTTGCATGGCGCTCGCGCGGGCCATCGGGCTCGATGCCGCGCCCACCG
AGATCCGCCGCGTGCAGGACCAGCCATTTCTGCTCGTTCAACGCTACGACCGTCTGGCCGTCCAGCCGTCCAACGCCCAG
CAAACGCCAGCAGCCACACAACGCCTGCACCAGGAAGACTTCTGCCAGGCCCTGGGCGTGCCGCCCGAGCTGAAATACCA
GAACGAGGGTGGCCCCGACTTGACCCAGGCCTTCGCCCTGGTGCGCAGCGCCACCCGCCCCAGCGCGCCCCAGCTCATCA
AGCTGCTGGACTTCGTGCTGTTCAACGCCCTCATCGGCAACCACGACGCCCACGCCAAGAACTTCTCACTGCTCTACACC
CCACTTGGCGCAGTGCTGGCTCCTATGTACGACGCGCTCTGCACCGCAGCCTACCCTGATCTGTCCGATCGCATGGCCAT
GAAGATCGGCAGCAAGTACCGTTTTACCGACCTCTACCCCCGACATTGGGCGCAGTTCGCCAGCGAAGCCGGGCTGTCAC
CCGCCCAGGTGAAAAAGGCCCTCAAGCGCGCCGCCGAGCGCCTGCCCGAACGTGCCCACCAGACCCAGGCCCAACTGGCC
GGGCAGGGCCACCAGCACGCCGTCATTGCGCAGATTGGCAAGCTCATTGAGGACCGCTGCGCCACCACCCTGCGCCGTCT
GGCCATGCCCAGCACCGCAACCGATTCAGATTCCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8259.61 Da        Isoelectric Point: 10.7043

>AT120266 WP_133157108.1 NZ_CP037867:c3269060-3268824 [Hydrogenophaga pseudoflava]
MAARIDSPTSLGQAVRRARKQLQLTQPQLALTAGVGVRFIVELEAGKPTVRLESVLRVLQALGGELQVDGLPTPSEGV

Download         Length: 237 bp

>AT120266 NZ_CP037867:c3269060-3268824 [Hydrogenophaga pseudoflava]
ATGGCCGCCCGCATCGACTCTCCCACCTCTCTCGGCCAGGCCGTGCGCCGCGCGCGCAAACAGCTGCAGCTCACCCAGCC
CCAGCTCGCCCTGACGGCCGGGGTTGGCGTGCGCTTCATCGTCGAGCTGGAAGCCGGCAAACCCACCGTGCGGCTCGAAA
GCGTGCTGCGCGTGCTGCAAGCCCTGGGAGGCGAACTGCAGGTCGATGGCCTGCCCACCCCGAGCGAGGGGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References