Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 824412..825052 | Replicon | chromosome |
| Accession | NZ_CP037865 | ||
| Organism | Pasteurella multocida subsp. multocida strain HN02 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | V4NDJ2 |
| Locus tag | E0Z11_RS04155 | Protein ID | WP_016533221.1 |
| Coordinates | 824412..824588 (+) | Length | 59 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | V4Q272 |
| Locus tag | E0Z11_RS04160 | Protein ID | WP_016533220.1 |
| Coordinates | 824636..825052 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| E0Z11_RS04125 | 819446..820375 | + | 930 | WP_139617790.1 | formate dehydrogenase accessory protein FdhE | - |
| E0Z11_RS04130 | 820947..822083 | - | 1137 | WP_139616922.1 | transposase | - |
| E0Z11_RS04135 | 822130..822546 | + | 417 | WP_006253505.1 | IS200/IS605 family transposase | - |
| E0Z11_RS04140 | 822614..822976 | - | 363 | Protein_782 | hypothetical protein | - |
| E0Z11_RS04145 | 823188..823676 | - | 489 | Protein_783 | phage terminase large subunit family protein | - |
| E0Z11_RS04150 | 823680..824153 | - | 474 | WP_139638922.1 | DUF1441 family protein | - |
| E0Z11_RS04155 | 824412..824588 | + | 177 | WP_016533221.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| E0Z11_RS04160 | 824636..825052 | + | 417 | WP_016533220.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| E0Z11_RS04170 | 825277..825600 | - | 324 | WP_078819663.1 | DUF2570 family protein | - |
| E0Z11_RS04175 | 825603..825956 | - | 354 | WP_139639369.1 | hypothetical protein | - |
| E0Z11_RS04180 | 825940..826128 | - | 189 | Protein_789 | hypothetical protein | - |
| E0Z11_RS04185 | 826236..826559 | - | 324 | WP_176558269.1 | replication protein | - |
| E0Z11_RS04190 | 826556..827308 | - | 753 | WP_139638717.1 | Rha family transcriptional regulator | - |
| E0Z11_RS04195 | 827364..827561 | - | 198 | WP_071523829.1 | hypothetical protein | - |
| E0Z11_RS04200 | 827564..828016 | - | 453 | WP_016570079.1 | hypothetical protein | - |
| E0Z11_RS04205 | 828066..828272 | - | 207 | WP_064965013.1 | helix-turn-helix domain-containing protein | - |
| E0Z11_RS04210 | 828411..829046 | + | 636 | WP_139638924.1 | LexA family transcriptional repressor | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 806761..846246 | 39485 | |
| - | flank | IS/Tn | - | - | 822130..822546 | 416 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6530.60 Da Isoelectric Point: 10.7333
>T120264 WP_016533221.1 NZ_CP037865:824412-824588 [Pasteurella multocida subsp. multocida]
MKQSEFLRWLKAQGVETKEGSNHIKLYLNGNQSALPRHPSKEIAKGTEIAVKKQLGLK
MKQSEFLRWLKAQGVETKEGSNHIKLYLNGNQSALPRHPSKEIAKGTEIAVKKQLGLK
Download Length: 177 bp
>T120264 NZ_CP037865:824412-824588 [Pasteurella multocida subsp. multocida]
ATGAAACAAAGTGAGTTTTTAAGATGGCTGAAAGCTCAAGGGGTAGAAACTAAAGAAGGCTCAAACCACATTAAGCTCTA
CCTAAACGGCAACCAATCAGCTCTCCCAAGACATCCAAGCAAAGAGATAGCCAAGGGAACTGAAATAGCAGTTAAAAAGC
AATTAGGTCTAAAATAA
ATGAAACAAAGTGAGTTTTTAAGATGGCTGAAAGCTCAAGGGGTAGAAACTAAAGAAGGCTCAAACCACATTAAGCTCTA
CCTAAACGGCAACCAATCAGCTCTCCCAAGACATCCAAGCAAAGAGATAGCCAAGGGAACTGAAATAGCAGTTAAAAAGC
AATTAGGTCTAAAATAA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15580.82 Da Isoelectric Point: 4.3715
>AT120264 WP_016533220.1 NZ_CP037865:824636-825052 [Pasteurella multocida subsp. multocida]
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFDDAVAMAKDALVTSMDFYFEDFRKVPLPTEPEQDEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV
MLYPAKFDKEDNGLYAVSFRDIPEALTCGDNFDDAVAMAKDALVTSMDFYFEDFRKVPLPTEPEQDEVLIELPDSVFAKV
LLLNEMVEQNISNAELARRINVRPQEMQRITNISHSTKIDTISRALSALGKKLQLSVV
Download Length: 417 bp
>AT120264 NZ_CP037865:824636-825052 [Pasteurella multocida subsp. multocida]
ATGTTATATCCAGCAAAATTTGATAAAGAAGATAATGGGCTTTATGCTGTATCATTTCGTGATATACCTGAAGCCTTAAC
TTGTGGTGATAACTTCGACGATGCCGTCGCAATGGCAAAAGATGCCTTGGTTACATCAATGGATTTTTACTTTGAGGACT
TCCGCAAAGTGCCATTACCAACCGAGCCAGAGCAAGATGAGGTATTAATCGAGTTACCAGATAGTGTTTTTGCTAAAGTG
CTTTTATTAAATGAGATGGTTGAACAAAATATCTCTAATGCTGAATTAGCAAGAAGAATTAATGTTCGACCACAGGAAAT
GCAACGCATTACTAATATCTCGCATAGCACAAAAATCGACACAATAAGCCGTGCTTTGTCAGCACTCGGTAAAAAACTAC
AACTTTCAGTCGTCTAA
ATGTTATATCCAGCAAAATTTGATAAAGAAGATAATGGGCTTTATGCTGTATCATTTCGTGATATACCTGAAGCCTTAAC
TTGTGGTGATAACTTCGACGATGCCGTCGCAATGGCAAAAGATGCCTTGGTTACATCAATGGATTTTTACTTTGAGGACT
TCCGCAAAGTGCCATTACCAACCGAGCCAGAGCAAGATGAGGTATTAATCGAGTTACCAGATAGTGTTTTTGCTAAAGTG
CTTTTATTAAATGAGATGGTTGAACAAAATATCTCTAATGCTGAATTAGCAAGAAGAATTAATGTTCGACCACAGGAAAT
GCAACGCATTACTAATATCTCGCATAGCACAAAAATCGACACAATAAGCCGTGCTTTGTCAGCACTCGGTAAAAAACTAC
AACTTTCAGTCGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|