Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4937126..4937745 Replicon chromosome
Accession NZ_CP037864
Organism Citrobacter sp. LY-1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E1B03_RS24855 Protein ID WP_133087089.1
Coordinates 4937482..4937745 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag E1B03_RS24850 Protein ID WP_133087088.1
Coordinates 4937126..4937485 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1B03_RS24820 4932222..4932887 + 666 WP_019078120.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -
E1B03_RS24825 4932960..4933517 + 558 WP_003827547.1 DcrB family lipoprotein -
E1B03_RS24830 4933521..4934738 - 1218 WP_103769545.1 MFS transporter -
E1B03_RS24835 4934872..4935921 + 1050 WP_103769544.1 AI-2E family transporter -
E1B03_RS24840 4935984..4936562 + 579 WP_103769543.1 4'-phosphopantetheinyl transferase AcpT -
E1B03_RS24845 4936612..4937013 + 402 WP_103769542.1 nickel-responsive transcriptional regulator NikR -
E1B03_RS24850 4937126..4937485 - 360 WP_133087088.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
E1B03_RS24855 4937482..4937745 - 264 WP_133087089.1 type II toxin-antitoxin system HicA family toxin Toxin
E1B03_RS24860 4937835..4938959 - 1125 WP_133087090.1 ABC transporter permease -
E1B03_RS24865 4938959..4941706 - 2748 WP_133087091.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(26-76)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 9662.27 Da        Isoelectric Point: 10.8620

>T120263 WP_133087089.1 NZ_CP037864:c4937745-4937482 [Citrobacter sp. LY-1]
VLSLRKKQKNTLVQLFKAPTPQGIKWAEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENVRDWL
TSIGVKP

Download         Length: 264 bp

>T120263 NZ_CP037864:c4937745-4937482 [Citrobacter sp. LY-1]
GTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGTTCAGCTTTTTAAAGCACCGACGCCGCAGGGAATTAAGTGGGC
GGAAATCGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAGTTTCTTTTAAATA
AGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTACGTGACTGGTTA
ACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13222.02 Da        Isoelectric Point: 4.7022

>AT120263 WP_133087088.1 NZ_CP037864:c4937485-4937126 [Citrobacter sp. LY-1]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYAHPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp

>AT120263 NZ_CP037864:c4937485-4937126 [Citrobacter sp. LY-1]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAGCCTGCGGTAATTAATTATGTTCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AAATTTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAGCCTTACGCACACCCGGAAAAGCTGAAGACA
TTTACTTTGCGCTATCCAGAATCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAGCAGGTATCAGTGAATACATG
GATCATCGAAACGCTTAGCAAAAGTCTCAAACAGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References