Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2522999..2523735 Replicon chromosome
Accession NZ_CP037864
Organism Citrobacter sp. LY-1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag E1B03_RS13210 Protein ID WP_103770575.1
Coordinates 2522999..2523481 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag E1B03_RS13215 Protein ID WP_103770576.1
Coordinates 2523469..2523735 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1B03_RS13180 2518672..2519586 + 915 WP_103769947.1 bestrophin family protein -
E1B03_RS13185 2519583..2519960 - 378 WP_133086358.1 GFA family protein -
E1B03_RS13190 2520092..2520850 - 759 WP_103769945.1 trans-aconitate 2-methyltransferase -
E1B03_RS13195 2520960..2521481 + 522 WP_103770278.1 GNAT family N-acetyltransferase -
E1B03_RS13200 2521482..2522327 - 846 WP_133086359.1 DMT family transporter -
E1B03_RS13205 2522381..2522605 - 225 Protein_2327 hypothetical protein -
E1B03_RS13210 2522999..2523481 - 483 WP_103770575.1 GNAT family N-acetyltransferase Toxin
E1B03_RS13215 2523469..2523735 - 267 WP_103770576.1 DUF1778 domain-containing protein Antitoxin
E1B03_RS13220 2523888..2525870 - 1983 WP_133086360.1 MBL fold metallo-hydrolase -
E1B03_RS13225 2526114..2526500 + 387 WP_103770578.1 hypothetical protein -
E1B03_RS13230 2526563..2527180 - 618 WP_103770579.1 outer membrane beta-barrel protein -
E1B03_RS13235 2527290..2527919 - 630 WP_133086361.1 winged helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17598.40 Da        Isoelectric Point: 9.9001

>T120252 WP_103770575.1 NZ_CP037864:c2523481-2522999 [Citrobacter sp. LY-1]
VGFVTAPEPLTHLHQLAEFVSGEIVLDDWLKQKGLKNQALGAARTFVVCKTNTRQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSVRGKGLGADLLHDAVLRCYKVADNIGVRAVMVHALTDEAKRFYIHHGFKASQLQERTLFLRLS

Download         Length: 483 bp

>T120252 NZ_CP037864:c2523481-2522999 [Citrobacter sp. LY-1]
GTGGGATTTGTAACTGCGCCTGAGCCGCTAACACATTTGCATCAATTGGCAGAATTTGTCAGCGGAGAAATTGTTCTCGA
TGATTGGTTAAAACAAAAAGGGCTGAAAAACCAGGCTCTCGGCGCTGCCCGGACGTTTGTTGTCTGCAAGACAAACACAC
GACAAGTGGCTGGTTTTTATTCACTGGCCACCGGCAGCGTCAACCATACAGAAGCAACAGGCAATCTTCGACGTAACATG
CCAGATCCAATCCCCGTAATTATCCTTGCCAGATTGGCGGTAGATCTTTCTGTTCGCGGAAAAGGGTTAGGGGCCGATCT
GCTTCACGATGCGGTGCTGCGGTGTTACAAAGTGGCGGATAATATTGGCGTGCGTGCCGTTATGGTGCATGCACTCACTG
ATGAGGCTAAACGCTTCTATATTCACCACGGTTTCAAAGCATCTCAACTGCAGGAACGAACTCTGTTCCTTCGGCTTTCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10173.67 Da        Isoelectric Point: 4.6677

>AT120252 WP_103770576.1 NZ_CP037864:c2523735-2523469 [Citrobacter sp. LY-1]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIEMLDAPVAEEPAIRKLL
ARKPQWDL

Download         Length: 267 bp

>AT120252 NZ_CP037864:c2523735-2523469 [Citrobacter sp. LY-1]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCCCAACGAGCGCTTATTGATGCGGCCGCAGAGATTCTACA
CAAATCGCGTACAGACTTTATTCTGGAAATGGCCTGTCAGGCGGCAGAGAACGTAATTCTCGATCGCCGAGTCTTTAATT
TTAATGATGAACAATACGCTGAGTTTATCGAGATGCTTGATGCTCCGGTTGCCGAAGAACCGGCCATCAGAAAGTTACTG
GCAAGGAAACCACAGTGGGATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References