Detailed information of TA system TA120250

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 1069505..1070325
• Replicon: chromosome
• Accession: NZ_CP037864
• Organism: Citrobacter sp. LY-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A4P6WIM7
• Locus tag: E1B03_RS06025
• Protein ID: WP_047057905.1
• Coordinates: 1070068..1070325 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: E1B03_RS06020
• Protein ID: WP_133085840.1
• Coordinates: 1069505..1070056 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1B03_RS05995	1065394..1066089	+	696	WP_103770978.1	molecular chaperone	-
E1B03_RS06000	1066608..1068056	+	1449	WP_133085839.1	EAL domain-containing protein	-
E1B03_RS06005	1068250..1068714	+	465	WP_103770980.1	isoprenylcysteine carboxylmethyltransferase family protein	-
E1B03_RS06015	1069008..1069262	-	255	WP_103770981.1	hypothetical protein	-
E1B03_RS06020	1069505..1070056	-	552	WP_133085840.1	N-acetyltransferase	Antitoxin
E1B03_RS06025	1070068..1070325	-	258	WP_047057905.1	YjhX family toxin	Toxin
E1B03_RS06030	1070662..1071924	-	1263	WP_103770983.1	PTS galactitol transporter subunit IIC	-
E1B03_RS06035	1072015..1073010	-	996	WP_133085841.1	2-hydroxyacid dehydrogenase	-
E1B03_RS06040	1073027..1073788	-	762	WP_103770985.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-122)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9566.10 Da
• Isoelectric Point: 11.1381

>T120250 WP_047057905.1 NZ_CP037864:c1070325-1070068 [Citrobacter sp. LY-1]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRITAVECYTREGLLLTDCTLATFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T120250 NZ_CP037864:c1070325-1070068 [Citrobacter sp. LY-1]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCCAAAGGTGGTCGAATCGCGCACGTCCGCGATGCATC
AGGCCGCATCACCGCCGTTGAATGCTACACCCGCGAAGGGCTGTTGCTCACCGACTGCACCCTCGCCACCTTCAAAAAAC
TCAAAACCAAAAAACTGATCAAATCCGTCAACGGTCAGCCCTATCGGATCAATACCACCGGGCTGAACAACGTTCGTGCT
CAGCTTGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20277.12 Da
• Isoelectric Point: 5.7684

>AT120250 WP_133085840.1 NZ_CP037864:c1070056-1069505 [Citrobacter sp. LY-1]
MTAHQFTFDITDERDASDIREVETRAFGFSKEADLAASLLEDESARPALSLLARHEGKAVGHILFTRATFKGTTDSPLMH
ILAPLAVIPEYQGMGVGGQLIRTGIEHLRLMGCQTVFVLGHATYYPKHGFEPCAEDKGYPAPYPIPEDHKACWMVQSLTA
QPIDVTGQIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT120250 NZ_CP037864:c1070056-1069505 [Citrobacter sp. LY-1]
ATGACAGCACACCAATTCACTTTTGATATCACAGACGAACGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGCGGCGTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCCACATTCAAGGGCACAACGGATTCACCTCTGATGCAT
ATCCTTGCCCCTCTGGCGGTTATACCGGAATACCAGGGGATGGGCGTGGGAGGACAGTTAATACGTACTGGCATAGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCATGCCACCTATTACCCAAAACATGGATTCGAACCCTGTG
CCGAAGACAAAGGCTATCCAGCACCTTATCCCATTCCAGAGGATCACAAAGCCTGCTGGATGGTGCAATCGCTCACAGCT
CAGCCAATTGATGTGACCGGCCAGATCCAGTGTGCTCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAG

Structures

Toxin

• AlphaFold DB: A0A4P6WIM7