Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2325440..2326041 Replicon chromosome
Accession NZ_CP037861
Organism Pasteurella multocida subsp. multocida strain HN01

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag E0L18_RS11740 Protein ID WP_139617776.1
Coordinates 2325440..2325754 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E0L18_RS11745 Protein ID WP_005720732.1
Coordinates 2325751..2326041 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0L18_RS11700 2320518..2321573 - 1056 WP_139617771.1 site-specific integrase -
E0L18_RS11705 2321477..2321776 - 300 WP_139617772.1 helix-turn-helix domain-containing protein -
E0L18_RS11710 2321805..2322017 - 213 WP_139617773.1 hypothetical protein -
E0L18_RS11720 2322365..2322661 - 297 WP_015691047.1 hypothetical protein -
E0L18_RS11725 2322730..2323383 - 654 WP_139617774.1 KilA-N domain-containing protein -
E0L18_RS11730 2323661..2324407 - 747 WP_132994684.1 damage-inducible protein D -
E0L18_RS11735 2324782..2325009 - 228 WP_139617775.1 hypothetical protein -
E0L18_RS11740 2325440..2325754 + 315 WP_139617776.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E0L18_RS11745 2325751..2326041 + 291 WP_005720732.1 putative addiction module antidote protein Antitoxin
E0L18_RS11750 2326062..2326571 - 510 WP_139617777.1 hypothetical protein -
E0L18_RS11755 2326684..2327076 - 393 WP_139617778.1 hypothetical protein -
E0L18_RS11760 2327176..2327865 - 690 WP_005720261.1 helix-turn-helix transcriptional regulator -
E0L18_RS11765 2327993..2328198 + 206 Protein_2267 helix-turn-helix transcriptional regulator -
E0L18_RS11770 2328404..2328808 - 405 WP_005753269.1 VOC family protein -
E0L18_RS11775 2328941..2329855 - 915 WP_139617779.1 c-type cytochrome biogenesis protein CcmI -
E0L18_RS11780 2329852..2330316 - 465 WP_139617780.1 cytochrome c-type biogenesis protein CcmH -
E0L18_RS11785 2330316..2330861 - 546 WP_005721337.1 DsbE family thiol:disulfide interchange protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2315050..2327865 12815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-89)

Antitoxin

Cro/C1-type helix-turn-helix domain

(49-91)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11745.60 Da        Isoelectric Point: 9.7746

>T120245 WP_139617776.1 NZ_CP037861:2325440-2325754 [Pasteurella multocida subsp. multocida]
MLDVIETTVFNKWLKELKDLSAKAAILARINRAKNGNFGDHKSVGDGLYEMRIMKGAGYRVYYAQYKDVTYLLICGGDKS
TQKADIAKAKALWEEIRQKEGVNV

Download         Length: 315 bp

>T120245 NZ_CP037861:2325440-2325754 [Pasteurella multocida subsp. multocida]
ATGCTCGATGTAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAAGATTTGTCGGCTAAGGCAGCTATTCT
TGCTCGTATTAATAGAGCTAAAAATGGTAATTTTGGCGATCATAAATCAGTTGGTGATGGTTTATATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATTGCTAAAGCAAAAGCGTTATGGGAAGAAATTAGGCAGAAAGAGGGGGTAAATGTATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10674.35 Da        Isoelectric Point: 4.8605

>AT120245 WP_005720732.1 NZ_CP037861:2325751-2326041 [Pasteurella multocida subsp. multocida]
MSKKVELKPFDIAEYLDSEEMIAAYLSEVLETGDTNEFISALGDVARARGMTELAEKTGLGRESLYKTLSYGSKPRFDTI
MKITQALGIKLVPMHI

Download         Length: 291 bp

>AT120245 NZ_CP037861:2325751-2326041 [Pasteurella multocida subsp. multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATATCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAGTTTTAGAAACAGGTGATACTAATGAATTTATTTCTGCGCTAGGTGATGTTGCAAGAGCGAGAGGAATGACGGAAT
TAGCAGAAAAAACGGGGTTGGGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGTAAGCCACGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCCATGCACATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References