Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 910307..910966 Replicon chromosome
Accession NZ_CP037861
Organism Pasteurella multocida subsp. multocida strain HN01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E0L18_RS04480 Protein ID WP_139617245.1
Coordinates 910307..910696 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E0L18_RS04485 Protein ID WP_005719980.1
Coordinates 910700..910966 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0L18_RS04465 905798..906526 - 729 WP_005716728.1 bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG -
E0L18_RS04470 906679..909360 + 2682 WP_139617244.1 DNA topoisomerase (ATP-hydrolyzing) subunit A -
E0L18_RS04475 909436..909804 + 369 WP_059245980.1 SirB2 family protein -
E0L18_RS11970 910075..910251 - 177 WP_176558157.1 hypothetical protein -
E0L18_RS04480 910307..910696 - 390 WP_139617245.1 type II toxin-antitoxin system VapC family toxin Toxin
E0L18_RS04485 910700..910966 - 267 WP_005719980.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E0L18_RS04490 911132..911569 + 438 WP_139617246.1 TIGR03757 family integrating conjugative element protein -
E0L18_RS04495 911641..912411 + 771 Protein_869 TIGR03756 family integrating conjugative element protein -
E0L18_RS04500 912399..913184 - 786 WP_139617797.1 ParB N-terminal domain-containing protein -
E0L18_RS04505 913199..914569 - 1371 WP_139617247.1 replicative DNA helicase -
E0L18_RS04510 914571..915416 - 846 WP_139617248.1 ParA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14366.77 Da        Isoelectric Point: 6.9463

>T120243 WP_139617245.1 NZ_CP037861:c910696-910307 [Pasteurella multocida subsp. multocida]
MFMLDTNTVSYFFKQIPAIVNKLTVVGPEKICISSVTAAELLYGVEKRQNKALRDGVTLFLDTVSVYPWDLSVATTYGKL
RSNMEKNGCVMGNLDLMIAAHALDLRYIPVTNDKAFSMVPGLNIENWLS

Download         Length: 390 bp

>T120243 NZ_CP037861:c910696-910307 [Pasteurella multocida subsp. multocida]
ATGTTTATGCTTGATACTAATACAGTGAGTTATTTCTTTAAGCAAATTCCTGCTATCGTGAATAAACTGACAGTCGTTGG
GCCTGAAAAAATTTGTATATCTTCCGTTACTGCAGCTGAGTTGCTTTATGGTGTAGAAAAACGCCAGAATAAAGCATTAC
GAGATGGTGTTACATTATTTTTAGATACGGTCTCGGTTTATCCGTGGGATCTGTCTGTTGCGACAACTTATGGAAAGTTA
CGTAGTAATATGGAAAAAAATGGGTGTGTAATGGGAAACTTGGATTTGATGATTGCTGCTCATGCCTTAGATTTGAGATA
TATTCCAGTAACGAATGATAAAGCATTTTCAATGGTTCCTGGATTAAATATTGAGAATTGGTTAAGTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10365.69 Da        Isoelectric Point: 5.1970

>AT120243 WP_005719980.1 NZ_CP037861:c910966-910700 [Pasteurella multocida subsp. multocida]
MERTARLFRNGRNQAVRLPVEFEFDAEQVYVRKEQNGDIVLSLTSSKEASWKNLFELLPKIKVCDDFLSQKERNQTTEVR
DPFSWVGE

Download         Length: 267 bp

>AT120243 NZ_CP037861:c910966-910700 [Pasteurella multocida subsp. multocida]
ATGGAAAGAACCGCAAGATTATTCAGAAATGGGCGTAATCAAGCCGTAAGGTTACCTGTTGAGTTTGAGTTTGATGCCGA
GCAAGTATATGTTCGTAAAGAACAAAATGGCGATATCGTACTTTCATTGACATCTTCAAAAGAAGCCTCTTGGAAAAATT
TATTTGAATTACTTCCAAAAATAAAAGTTTGTGATGACTTTCTCAGTCAAAAAGAACGTAACCAAACAACGGAAGTTAGA
GATCCATTTTCTTGGGTAGGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References