Detailed information of TA system TA120242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 204849..205502
• Replicon: chromosome
• Accession: NZ_CP037861
• Organism: Pasteurella multocida subsp. multocida strain HN01

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: E0L18_RS01110
• Protein ID: WP_139616967.1
• Coordinates: 205113..205502 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: E0L18_RS01105
• Protein ID: WP_139616966.1
• Coordinates: 204849..205109 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0L18_RS01085	200869..201231	-	363	WP_139616963.1	hypothetical protein	-
E0L18_RS01090	201240..203212	-	1973	Protein_209	integrating conjugative element protein	-
E0L18_RS01095	203218..204165	-	948	WP_139616964.1	TIGR03756 family integrating conjugative element protein	-
E0L18_RS01100	204162..204599	-	438	WP_139616965.1	TIGR03757 family integrating conjugative element protein	-
E0L18_RS01105	204849..205109	+	261	WP_139616966.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
E0L18_RS01110	205113..205502	+	390	WP_139616967.1	type II toxin-antitoxin system VapC family toxin	Toxin
E0L18_RS01120	205726..206766	+	1041	WP_005720395.1	IS481 family transposase	-
E0L18_RS01125	206892..207149	+	258	WP_139616968.1	hypothetical protein	-
E0L18_RS01130	207167..208690	-	1524	WP_139616969.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
E0L18_RS01135	208697..209026	-	330	WP_139616970.1	hypothetical protein	-
E0L18_RS01140	209032..209484	-	453	WP_139616971.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	205726..206766	1040

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14540.93 Da
• Isoelectric Point: 6.4517

>T120242 WP_139616967.1 NZ_CP037861:205113-205502 [Pasteurella multocida subsp. multocida]
MFMLDTNTVSYFFKQIPAIVNKLTVIGHEQICISSVTAAELLYGVEKRQNRALRDSVTLFLDTVSVYQWDLSVATTYGKL
RSKMEKNGCVMGNLDLMIAAHALDLRYILVTNDKAFSMVPGLDIENWLS

Nucleotide

• Length: 390 bp

>T120242 NZ_CP037861:205113-205502 [Pasteurella multocida subsp. multocida]
ATGTTTATGCTTGATACTAATACGGTGAGCTATTTTTTTAAGCAAATTCCTGCCATTGTAAATAAACTAACAGTCATTGG
ACATGAACAAATTTGTATTTCTTCTGTTACTGCAGCTGAGTTGCTTTATGGTGTAGAAAAACGCCAGAATAGAGCATTAC
GAGACAGTGTTACACTATTTTTAGATACAGTCTCGGTTTATCAGTGGGATCTGTCTGTTGCGACAACTTATGGAAAATTA
CGCAGTAAGATGGAAAAAAATGGGTGTGTAATGGGGAATTTAGATTTGATGATTGCTGCTCATGCCTTAGATTTGAGATA
TATTCTAGTAACGAATGATAAAGCATTTTCAATGGTTCCAGGATTAGATATTGAGAATTGGTTAAGTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10049.30 Da
• Isoelectric Point: 4.6820

>AT120242 WP_139616966.1 NZ_CP037861:204849-205109 [Pasteurella multocida subsp. multocida]
MERTARLFRNGRNQAVRLPVEFDAEQVYVRKEQNGDIVLSLTSSKEASWKQLFKLLPEIKDCDDFLSQEERNQTMAVRDP
FSEIGE

Nucleotide

• Length: 261 bp

>AT120242 NZ_CP037861:204849-205109 [Pasteurella multocida subsp. multocida]
ATGGAAAGAACAGCAAGATTATTCAGAAATGGGCGTAATCAAGCCGTAAGATTACCTGTTGAGTTTGATGCCGAGCAAGT
ATATGTTCGTAAAGAACAAAATGGCGATATTGTACTTTCATTGACATCTTCAAAAGAAGCCTCTTGGAAACAGTTATTTA
AATTGCTTCCAGAAATAAAAGATTGTGATGACTTCCTTAGCCAAGAGGAACGCAACCAAACGATGGCAGTTAGAGATCCG
TTTTCTGAGATAGGTGAATAA