Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 4369567..4371150 Replicon chromosome
Accession NZ_CP037858
Organism Stenotrophomonas maltophilia strain X28

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag EZ304_RS20140 Protein ID WP_142807967.1
Coordinates 4369828..4371150 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag EZ304_RS20135 Protein ID WP_099552530.1
Coordinates 4369567..4369824 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EZ304_RS20125 4364911..4365546 - 636 WP_099552526.1 hypothetical protein -
EZ304_RS20130 4365719..4369405 + 3687 WP_142807966.1 indolepyruvate ferredoxin oxidoreductase family protein -
EZ304_RS20135 4369567..4369824 + 258 WP_099552530.1 helix-turn-helix transcriptional regulator Antitoxin
EZ304_RS20140 4369828..4371150 + 1323 WP_142807967.1 type II toxin-antitoxin system HipA family toxin Toxin
EZ304_RS20145 4371151..4371765 - 615 WP_099552529.1 DUF938 domain-containing protein -
EZ304_RS20150 4372467..4374098 + 1632 WP_185959203.1 TldD/PmbA family protein -
EZ304_RS20155 4374129..4375763 + 1635 WP_099552766.1 TldD/PmbA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(19-70)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49114.96 Da        Isoelectric Point: 6.6336

>T120240 WP_142807967.1 NZ_CP037858:4369828-4371150 [Stenotrophomonas maltophilia]
MGTLRVWMNGVEVARWDDVRNGSSRLSYVSQWISSPQSRPLSLSLPLLPDGESHRGNVVNDYFDNLLPDNVTIRNRIRDR
FATRGSDTFDLLEAIGRDCVGAVQLLPPAYPPEDVQQITCEVLDEAGVATILRQVTTGNLPGAPSRDDAFRISIAGAQEK
TGLLLHAGQWCIPTGSTPSTHIFKLPLGIVGNMRADMHQSVENEWLCMHLLSAFDIPVAETQMGRFDDQRALIVERFDRR
LSVDRRWWLRLPQEDMCQVFGLPAARKYESDGGPGIVPIMDLLRQSEHPEDRAIFFKTQILFWMLAATDGHAKNFSVHLE
AGGRFRLTPVYDVLSVYPILGRGPNQLDPRNAQLAMAVHGKNRHRKLHLVQRRHWNETARACGVADGAEPWIKTLIAAVE
PAIQQVTRQLPDDFPSTVSEPIFDGLRAAAARLSSMAPEA

Download         Length: 1323 bp

>T120240 NZ_CP037858:4369828-4371150 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCGGGTCTGGATGAATGGTGTGGAGGTCGCACGTTGGGATGATGTCCGGAACGGGTCATCCCGGTTGTC
GTACGTCAGCCAGTGGATCAGCTCGCCCCAATCCCGGCCGTTGTCGCTCTCGCTACCCCTGCTCCCAGATGGCGAGAGCC
ATCGGGGCAACGTCGTCAACGACTACTTCGATAACCTTCTTCCCGATAACGTCACCATACGCAACCGGATCCGCGACCGG
TTTGCCACGCGCGGTAGCGATACGTTCGATCTTCTTGAAGCCATTGGACGAGATTGTGTTGGCGCAGTGCAGCTGTTGCC
GCCTGCGTATCCACCCGAAGACGTCCAGCAGATTACGTGCGAGGTGTTGGATGAAGCAGGTGTCGCTACGATCCTGCGTC
AGGTAACGACAGGGAACCTGCCTGGCGCACCCAGCCGTGATGACGCATTCCGTATTTCCATCGCCGGTGCGCAGGAAAAA
ACCGGTCTTCTGCTGCATGCTGGCCAATGGTGCATTCCTACCGGCAGCACACCGTCCACGCACATCTTCAAGCTGCCGCT
TGGCATCGTTGGCAACATGCGCGCAGACATGCATCAGTCCGTGGAGAATGAATGGCTGTGCATGCATCTGCTTTCCGCCT
TTGATATCCCCGTGGCCGAGACGCAGATGGGTCGCTTCGACGACCAACGTGCCCTCATTGTCGAGCGGTTTGACCGTCGC
CTGTCTGTCGACCGCCGGTGGTGGCTGCGACTGCCACAGGAAGACATGTGCCAGGTCTTTGGTCTGCCGGCTGCCAGAAA
GTATGAATCCGATGGCGGCCCGGGCATCGTTCCGATCATGGATCTGCTTCGACAGTCCGAACACCCCGAGGATCGCGCGA
TCTTCTTCAAGACGCAGATTCTTTTCTGGATGCTGGCCGCAACCGACGGTCATGCCAAGAATTTCAGTGTTCACCTGGAA
GCCGGTGGACGCTTCCGCCTGACGCCCGTCTACGACGTACTGTCGGTATATCCCATCCTCGGCAGGGGACCCAATCAACT
CGATCCACGAAATGCACAGCTCGCCATGGCCGTACATGGCAAGAACCGCCACCGGAAACTGCACCTTGTGCAACGGCGGC
ACTGGAATGAAACCGCGCGCGCCTGCGGCGTTGCCGATGGTGCAGAACCATGGATCAAGACATTGATCGCGGCCGTCGAA
CCCGCCATCCAGCAGGTCACCCGTCAGCTCCCGGATGATTTCCCCTCAACCGTGTCCGAACCGATTTTCGACGGACTTCG
TGCTGCGGCAGCACGCCTTTCCAGCATGGCCCCCGAGGCCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9612.94 Da        Isoelectric Point: 11.5457

>AT120240 WP_099552530.1 NZ_CP037858:4369567-4369824 [Stenotrophomonas maltophilia]
MDRPLHTVRTAQQLTPLMRAFRRQAGLSQAQLAEQLGISRQAVGALERDPASASFERLMRVWAVLGLEVSLQQRSHQENT
SSLEW

Download         Length: 258 bp

>AT120240 NZ_CP037858:4369567-4369824 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACAGTGAGGACAGCCCAACAACTTACGCCCCTGATGCGTGCTTTCCGGCGCCAGGCGGGCCT
GAGCCAGGCTCAGTTGGCGGAGCAACTCGGGATCAGCCGCCAAGCAGTGGGCGCGCTGGAACGCGACCCTGCGTCGGCAA
GCTTTGAACGCCTGATGCGGGTCTGGGCTGTGCTGGGTCTGGAGGTCAGCCTTCAGCAACGAAGTCACCAGGAGAACACG
TCGTCATTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References