Detailed information of TA system TA120009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 8034..8977
• Replicon: plasmid unnamed2
• Accession: NZ_CP037748
• Organism: Campylobacter helveticus strain 2013D-9613

Toxin (Protein)

• Gene name: Fic
• Uniprot ID: -
• Locus tag: A0073_RS09675
• Protein ID: WP_082200908.1
• Coordinates: 8034..8738 (-)
• Length: 235 a.a.

Antitoxin (Protein)

• Gene name: Fti
• Uniprot ID: -
• Locus tag: A0073_RS09680
• Protein ID: WP_082200884.1
• Coordinates: 8738..8977 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A0073_RS09665	6945..7193	-	249	WP_004276319.1	hypothetical protein	-
A0073_RS09670	7246..7905	-	660	WP_131937900.1	ParA family protein	-
A0073_RS09675	8034..8738	-	705	WP_082200908.1	Fic family protein	Toxin
A0073_RS09680	8738..8977	-	240	WP_082200884.1	hypothetical protein	Antitoxin
A0073_RS09685	9017..9439	-	423	WP_082200885.1	vapd	-
A0073_RS09690	9436..9765	-	330	WP_004276316.1	hypothetical protein	-
A0073_RS09695	10031..10876	-	846	WP_115633396.1	hypothetical protein	-
A0073_RS09700	10876..13047	-	2172	WP_131937902.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
A0073_RS09705	13145..13765	-	621	WP_082200888.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..42332	42332

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (53-157)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 235 a.a.
• Molecular weight: 27255.21 Da
• Isoelectric Point: 7.4007

>T120009 WP_082200908.1 NZ_CP037748:c8738-8034 [Campylobacter helveticus]
MWDTQDTYTDIDTFLLSTNKVNATSLSDLEHKERILAQLAMQELSKNEIKGNFNYEHLKAIHQFIFKDIYTWAGKDRYEE
KFFKALHKGDSQFCVGVLIPQESKRIFDGLMEKELLKTCKNDEQFIKELANFMADLNAMHPFCEGNGRTQRIFINQLAKN
AGYELDLNLTPKEIMLRASIEAMNHQNSSLEKIIKNNLKKIDMSKQREIEAMQEAVRKASQNLKPKDKSKDLDR

Nucleotide

• Length: 705 bp

>T120009 NZ_CP037748:c8738-8034 [Campylobacter helveticus]
ATGTGGGATACCCAAGATACATATACGGATATTGATACATTTTTACTCTCCACAAATAAGGTTAATGCAACTTCATTAAG
TGATTTAGAACACAAAGAAAGAATACTCGCTCAACTAGCAATGCAAGAACTCAGCAAAAATGAAATAAAAGGTAATTTTA
ACTACGAACACCTAAAAGCAATTCATCAATTTATTTTTAAAGATATTTACACTTGGGCTGGAAAAGACAGATATGAAGAA
AAATTTTTTAAGGCTTTACATAAAGGCGATTCTCAATTTTGTGTTGGCGTTTTAATCCCACAAGAATCAAAAAGAATATT
TGATGGTTTAATGGAAAAAGAATTGCTAAAAACTTGCAAAAATGATGAACAATTTATCAAAGAATTGGCAAATTTTATGG
CTGATTTAAACGCTATGCATCCATTTTGCGAGGGTAATGGACGCACTCAAAGAATTTTTATTAATCAACTTGCAAAAAAT
GCTGGATATGAACTTGATTTGAACTTAACTCCAAAAGAAATTATGCTTCGAGCTTCTATTGAAGCAATGAATCATCAAAA
TAGCTCTTTAGAAAAAATAATCAAAAACAATTTAAAGAAAATTGATATGTCTAAACAGAGGGAAATCGAAGCGATGCAAG
AAGCGGTTAGAAAAGCTTCGCAAAATCTTAAACCTAAAGATAAGAGCAAAGATTTAGATAGATAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9094.37 Da
• Isoelectric Point: 4.6652

>AT120009 WP_082200884.1 NZ_CP037748:c8977-8738 [Campylobacter helveticus]
MLQNCKEVYSLEESLNILNKYANNLTPRQYDNIKSIICSFAIENMHLNEEDILNGIAIQKGDKSVLEITQNYKAQWGCL

Nucleotide

• Length: 240 bp

>AT120009 NZ_CP037748:c8977-8738 [Campylobacter helveticus]
ATGTTGCAAAATTGTAAAGAAGTTTATAGCTTAGAAGAAAGCCTAAATATTTTAAATAAATATGCAAATAATCTCACACC
AAGACAATACGATAATATTAAGTCTATTATATGTAGCTTTGCCATAGAAAATATGCATCTCAATGAAGAAGATATTTTAA
ACGGCATAGCCATTCAAAAAGGCGATAAGAGTGTTTTAGAAATTACTCAAAATTATAAAGCTCAGTGGGGTTGCCTTTAA