Detailed information of TA system TA120007

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 282188..282812
• Replicon: chromosome
• Accession: NZ_CP037747
• Organism: Campylobacter helveticus strain 2013D-9613

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: A0073_RS01530
• Protein ID: WP_131936311.1
• Coordinates: 282411..282812 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: A0073_RS01525
• Protein ID: WP_131936309.1
• Coordinates: 282188..282430 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A0073_RS01485	277212..277928	-	717	WP_131936292.1	DUF2726 domain-containing protein	-
A0073_RS01490	277941..278204	-	264	WP_131936294.1	hypothetical protein	-
A0073_RS01495	278248..278424	-	177	WP_131936296.1	type II toxin-antitoxin system HicA family toxin	-
A0073_RS01500	278417..278638	-	222	WP_131936299.1	type II toxin-antitoxin system HicB family antitoxin	-
A0073_RS01505	278635..278820	-	186	WP_131936301.1	hypothetical protein	-
A0073_RS01510	278840..279916	-	1077	WP_131936303.1	DUF3825 domain-containing protein	-
A0073_RS01515	280066..280416	+	351	WP_131936305.1	hypothetical protein	-
A0073_RS01520	280413..282098	+	1686	WP_131936307.1	Bro-N domain-containing protein	-
A0073_RS01525	282188..282430	+	243	WP_131936309.1	hypothetical protein	Antitoxin
A0073_RS01530	282411..282812	+	402	WP_131936311.1	type II toxin-antitoxin system VapC family toxin	Toxin
A0073_RS01535	282937..283362	-	426	WP_131936313.1	thioredoxin family protein	-
A0073_RS01540	283511..284452	-	942	WP_131936315.1	hypothetical protein	-
A0073_RS01545	284700..285674	-	975	WP_131937827.1	TraU family protein	-
A0073_RS01550	285698..286435	-	738	WP_131936317.1	chromosome segregation protein ParM	-
A0073_RS01555	286435..287211	-	777	WP_082199873.1	conjugal transfer protein TraF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	254977..336504	81527

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15390.05 Da
• Isoelectric Point: 8.9205

>T120007 WP_131936311.1 NZ_CP037747:282411-282812 [Campylobacter helveticus]
MAKYLLDTNILIYLINHNPKSVEEKIKTLKIGALSTCSIVVSELYFGVEKSKYKEQNQKALETILKSFVVYDFGLKEAEE
YAKLRFELERDKSLIGNMDMLIASCARANHLILVTNNEKEFKRIKGLKIENWI

Nucleotide

• Length: 402 bp

>T120007 NZ_CP037747:282411-282812 [Campylobacter helveticus]
ATGGCGAAGTATTTGCTTGATACAAATATTTTAATTTATCTCATCAATCATAATCCAAAGAGCGTGGAGGAAAAAATAAA
AACTTTAAAAATAGGTGCATTAAGCACTTGTTCTATCGTAGTAAGTGAGCTTTATTTTGGTGTAGAAAAATCAAAATATA
AAGAGCAAAATCAAAAAGCTTTAGAAACAATACTAAAGTCTTTTGTCGTCTATGATTTTGGATTGAAAGAGGCTGAGGAA
TACGCAAAACTTAGATTTGAATTAGAGCGAGATAAAAGTCTTATTGGTAATATGGATATGCTTATTGCCTCTTGTGCGAG
AGCAAATCATCTTATTTTAGTTACAAATAATGAAAAAGAATTTAAAAGAATCAAAGGACTCAAAATAGAAAATTGGATTT
GA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9300.75 Da
• Isoelectric Point: 8.5312

>AT120007 WP_131936309.1 NZ_CP037747:282188-282430 [Campylobacter helveticus]
MLAKVFKSGNSMAIRIPKAIDLKNIKEFDIQVLDNNLILSPKKQENEWQSFFKALGDFKEPLKREKDEIPQSRDYGEVFA

Nucleotide

• Length: 243 bp

>AT120007 NZ_CP037747:282188-282430 [Campylobacter helveticus]
ATGTTGGCAAAGGTTTTTAAAAGTGGCAATTCTATGGCAATTAGAATTCCAAAAGCTATTGATTTGAAAAACATTAAAGA
ATTTGATATACAAGTTTTAGATAATAATTTAATTCTTAGTCCTAAAAAGCAAGAGAATGAGTGGCAAAGTTTTTTTAAAG
CACTCGGTGATTTTAAAGAGCCTTTAAAAAGAGAAAAAGATGAAATTCCGCAAAGTAGAGATTATGGCGAAGTATTTGCT
TGA