Detailed information of TA system TA120006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 142778..143909
• Replicon: chromosome
• Accession: NZ_CP037746
• Organism: Campylobacter volucris strain 2014D-0083

Toxin (Protein)

• Gene name: panT
• Uniprot ID: A0A5C8KXZ5
• Locus tag: A9460_RS00700
• Protein ID: WP_039666119.1
• Coordinates: 143196..143909 (+)
• Length: 238 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: A9460_RS00695
• Protein ID: WP_039666120.1
• Coordinates: 142778..143206 (+)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A9460_RS00690	140838..142637	+	1800	WP_039666121.1	hypothetical protein	-
A9460_RS00695	142778..143206	+	429	WP_039666120.1	DUF4065 domain-containing protein	Antitoxin
A9460_RS00700	143196..143909	+	714	WP_039666119.1	hypothetical protein	Toxin
A9460_RS00705	144095..145750	+	1656	WP_039666118.1	L-lactate permease	-
A9460_RS00710	145759..146496	+	738	WP_039666117.1	NAD-independent L-lactate dehydrogenase, oxidoreductase subunit	-
A9460_RS00715	146493..147908	+	1416	WP_039666116.1	iron-sulfur cluster-binding protein	-
A9460_RS00720	147901..148551	+	651	WP_039666115.1	NAD-independent L-lactate dehydrogenase subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-117)

Sequences

Toxin

Protein

• Length: 238 a.a.
• Molecular weight: 28025.80 Da
• Isoelectric Point: 6.6867

>T120006 WP_039666119.1 NZ_CP037746:143196-143909 [Campylobacter volucris]
MSFKKEHKELKVIIEKIYNEQSLESSCDDIVEKLITIYKTEYKHKYSELTTIILNITKSDREQDLMTLAQNVRMLEEKLD
NKTCDECIKEKIKDFYDHINLECVRLQDSDGKIKKIKDEYNELYKNYNNIKDNLSKQQTQYITILGIFASIVLTFVSGLV
FSTSVLSNIDKVSIFRLIFTMAFIAFFVGNILYSLFAFLLKISSIYSCKSNIYIYVFNLIIFLIMLIDFCFYLYCFY

Nucleotide

• Length: 714 bp

>T120006 NZ_CP037746:143196-143909 [Campylobacter volucris]
ATGAGTTTTAAAAAAGAACATAAGGAACTAAAAGTAATTATAGAAAAAATATATAATGAGCAAAGCTTAGAAAGTAGTTG
TGATGACATTGTAGAAAAATTAATCACAATTTATAAAACAGAATATAAGCATAAGTATTCAGAGCTTACGACGATAATAT
TAAATATTACAAAAAGCGATAGAGAGCAAGATTTAATGACATTAGCTCAAAATGTTAGAATGCTTGAAGAAAAATTAGAT
AACAAAACTTGCGATGAGTGTATTAAAGAAAAAATTAAAGATTTTTATGATCATATTAATTTAGAGTGTGTCAGGTTACA
AGATTCTGATGGTAAAATAAAAAAGATAAAAGATGAATATAATGAGCTTTATAAAAATTACAATAATATAAAAGATAACC
TTAGTAAGCAACAAACTCAATATATTACTATTTTAGGTATTTTTGCTTCTATTGTTTTGACTTTTGTTAGCGGTTTGGTT
TTTTCAACTTCTGTATTGTCAAATATAGATAAAGTAAGTATTTTTAGATTAATTTTTACTATGGCTTTTATAGCTTTTTT
TGTAGGAAATATTCTTTATTCTTTATTTGCTTTTCTTTTAAAAATTTCTTCAATATATAGTTGTAAAAGTAATATTTACA
TTTATGTTTTTAATTTAATTATATTTTTAATTATGCTTATTGATTTTTGTTTTTATTTGTATTGTTTTTATTAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 16908.10 Da
• Isoelectric Point: 5.3615

>AT120006 WP_039666120.1 NZ_CP037746:142778-143206 [Campylobacter volucris]
MVNALDLAKYILYKSDKDLSNLELQKTLYFTELDYIKKFDKHLINDDFEAWKYGPVARDVYCEYRNYGANSIDKPNDEIQ
LNLDNDELEIINNSIKKCNKQSYWILVEKSHRKGGAWEQSFKENKKEVINKELIKQEAKNEF

Nucleotide

• Length: 429 bp

>AT120006 NZ_CP037746:142778-143206 [Campylobacter volucris]
ATGGTTAATGCTTTAGATTTAGCAAAATATATTCTTTATAAATCAGATAAAGATTTGAGTAATTTAGAACTACAAAAAAC
TTTATATTTTACAGAACTTGATTATATTAAAAAATTTGATAAACATCTTATTAATGATGATTTTGAAGCTTGGAAGTATG
GTCCTGTTGCTAGAGATGTTTATTGCGAATATAGAAATTATGGGGCTAATTCTATAGATAAACCTAACGATGAAATTCAA
TTAAATCTTGATAATGATGAGTTGGAAATAATTAATAATTCGATTAAAAAATGCAATAAACAATCTTATTGGATTCTTGT
TGAAAAAAGTCATAGAAAAGGTGGAGCGTGGGAGCAGAGTTTTAAAGAAAATAAAAAGGAAGTTATCAATAAGGAATTAA
TAAAACAAGAAGCCAAAAATGAGTTTTAA

Structures

Toxin

• AlphaFold DB: A0A5C8KXZ5