Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 642368..643002 Replicon chromosome
Accession NZ_CP037745
Organism Rheinheimera sp. D18

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E0Z06_RS03080 Protein ID WP_132581793.1
Coordinates 642368..642769 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E0Z06_RS03085 Protein ID WP_132581795.1
Coordinates 642769..643002 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0Z06_RS03050 637500..638876 - 1377 WP_165907367.1 GAF domain-containing protein -
E0Z06_RS03055 639051..639851 - 801 WP_132581788.1 PEP-CTERM/exosortase system-associated acyltransferase -
E0Z06_RS03060 640155..640604 - 450 WP_132581789.1 MarR family transcriptional regulator -
E0Z06_RS03065 640767..641183 + 417 WP_132586657.1 organic hydroperoxide resistance protein -
E0Z06_RS03070 641349..641888 - 540 WP_132581791.1 DUF4468 domain-containing protein -
E0Z06_RS03075 642043..642201 - 159 Protein_604 tyrosine-type recombinase/integrase -
E0Z06_RS03080 642368..642769 - 402 WP_132581793.1 type II toxin-antitoxin system VapC family toxin Toxin
E0Z06_RS03085 642769..643002 - 234 WP_132581795.1 antitoxin Antitoxin
E0Z06_RS03095 643682..644164 - 483 WP_132581797.1 SsrA-binding protein SmpB -
E0Z06_RS03100 644270..644713 + 444 WP_132581799.1 type II toxin-antitoxin system RatA family toxin -
E0Z06_RS03105 644706..645053 + 348 WP_132581801.1 RnfH family protein -
E0Z06_RS03110 645093..645443 - 351 WP_132581803.1 outer membrane protein assembly factor BamE -
E0Z06_RS03115 645511..647184 - 1674 WP_132581805.1 DNA repair protein RecN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15205.47 Da        Isoelectric Point: 6.8542

>T120004 WP_132581793.1 NZ_CP037745:c642769-642368 [Rheinheimera sp. D18]
MLKYMLDTNICIYVIKRRPIEVLETFNKYAGLMCISSITYAELCHGVEKSTKPEQNRQAVEDFVSRLTILQYGEKAAQHY
GEVRAELEKAGTPIGVNDLHISAHARSESLTLVTNNMKEFERVQGLRLENWIS

Download         Length: 402 bp

>T120004 NZ_CP037745:c642769-642368 [Rheinheimera sp. D18]
ATGCTGAAATACATGCTTGATACCAATATATGCATTTACGTGATAAAACGCCGCCCAATTGAAGTACTAGAAACTTTTAA
CAAGTACGCAGGGTTAATGTGCATTAGCTCAATAACATACGCAGAGCTTTGTCATGGTGTAGAAAAAAGTACTAAGCCTG
AACAAAACCGGCAAGCAGTAGAAGATTTTGTTTCTAGATTAACTATTTTACAATATGGTGAAAAAGCAGCACAGCACTAT
GGTGAAGTCAGAGCTGAGCTAGAAAAAGCAGGCACTCCGATTGGTGTTAACGACTTGCATATTAGTGCGCACGCTAGAAG
CGAAAGTTTGACTTTAGTTACAAATAACATGAAAGAGTTTGAACGTGTACAAGGTCTACGATTAGAAAATTGGATAAGTT
AA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8766.82 Da        Isoelectric Point: 4.9987

>AT120004 WP_132581795.1 NZ_CP037745:c643002-642769 [Rheinheimera sp. D18]
MSTGTVFKNNNTQAVRLPIDARFPDDVKKVAVRIVGKDRILTPVTNSWDSFFLQGTTVTDDFMTERASQEQQEREAF

Download         Length: 234 bp

>AT120004 NZ_CP037745:c643002-642769 [Rheinheimera sp. D18]
ATGAGTACAGGTACAGTGTTTAAAAACAATAATACTCAAGCAGTTCGCTTGCCAATTGACGCCCGCTTTCCTGATGATGT
TAAAAAGGTCGCGGTTCGTATAGTCGGTAAAGACCGCATATTAACCCCTGTGACTAACAGCTGGGATTCGTTTTTCTTGC
AAGGTACAACTGTTACTGATGACTTTATGACTGAACGGGCATCGCAAGAACAGCAAGAACGGGAAGCCTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References