Detailed information of TA system TA120002

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 237712..238259
• Replicon: chromosome
• Accession: NZ_CP037745
• Organism: Rheinheimera sp. D18

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E0Z06_RS01175
• Protein ID: WP_113905686.1
• Coordinates: 237957..238259 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U7FV42
• Locus tag: E0Z06_RS01170
• Protein ID: WP_022990189.1
• Coordinates: 237712..237969 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0Z06_RS01140	232729..233325	+	597	WP_207903163.1	GNAT family N-acetyltransferase	-
E0Z06_RS01145	233483..233941	+	459	WP_132581124.1	hypothetical protein	-
E0Z06_RS01150	234399..235412	+	1014	WP_132581125.1	S41 family peptidase	-
E0Z06_RS01155	235528..235971	+	444	WP_132581126.1	VOC family protein	-
E0Z06_RS01160	236594..237175	+	582	WP_207903164.1	hypothetical protein	-
E0Z06_RS01165	237278..237559	+	282	WP_132581128.1	hypothetical protein	-
E0Z06_RS01170	237712..237969	+	258	WP_022990189.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
E0Z06_RS01175	237957..238259	+	303	WP_113905686.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E0Z06_RS01180	238355..238897	+	543	WP_132581129.1	hypothetical protein	-
E0Z06_RS01185	238993..239265	+	273	WP_132581130.1	ribbon-helix-helix protein, CopG family	-
E0Z06_RS01190	239262..239543	+	282	WP_132581131.1	type II toxin-antitoxin system RelE/ParE family toxin	-
E0Z06_RS01195	239641..240093	+	453	WP_132581132.1	isoprenylcysteine carboxylmethyltransferase family protein	-
E0Z06_RS01200	240382..240657	+	276	WP_132581133.1	DUF2127 domain-containing protein	-
E0Z06_RS01205	240771..241610	+	840	WP_132581134.1	rhombotarget lipoprotein	-
E0Z06_RS01210	241912..242181	+	270	WP_132586626.1	serine acetyltransferase	-
E0Z06_RS01215	242537..242881	+	345	WP_132581136.1	DMT family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	217333..239543	22210

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11510.23 Da
• Isoelectric Point: 4.3648

>T120002 WP_113905686.1 NZ_CP037745:237957-238259 [Rheinheimera sp. D18]
MAEVIWTEPALQELDAIAEYIALDNPAAASDLVKEVFGKAERLENFPKSGRIPPELPDSVYREVVVPPCRIFYREDEQRV
LVLYVMREERQLRAFMLGNS

Nucleotide

• Length: 303 bp

>T120002 NZ_CP037745:237957-238259 [Rheinheimera sp. D18]
ATGGCTGAAGTAATCTGGACAGAGCCAGCCCTCCAAGAACTTGATGCTATTGCTGAGTATATTGCTTTGGACAATCCTGC
TGCCGCAAGCGATCTCGTTAAGGAAGTTTTCGGTAAGGCAGAGCGTTTGGAAAATTTCCCCAAATCGGGGCGAATTCCTC
CAGAGCTCCCGGATTCGGTATACAGGGAGGTAGTGGTTCCACCGTGTCGCATTTTTTATCGTGAGGATGAGCAGCGGGTT
CTCGTCCTCTATGTCATGCGAGAGGAGCGGCAACTTCGTGCGTTCATGCTTGGAAACAGCTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9887.41 Da
• Isoelectric Point: 8.5042

>AT120002 WP_022990189.1 NZ_CP037745:237712-237969 [Rheinheimera sp. D18]
MKVELVTNLKRQATKILADLHLSKEPVLITEHGQPSAYLVDVQDYEFMQRRLELLEGLSRGERAVLEGRTYSQSEAREKM
SKWLK

Nucleotide

• Length: 258 bp

>AT120002 NZ_CP037745:237712-237969 [Rheinheimera sp. D18]
ATGAAAGTTGAGCTAGTTACGAACCTCAAGCGCCAAGCTACAAAGATTCTCGCAGATCTGCACTTGTCGAAAGAGCCCGT
ATTGATTACGGAGCATGGCCAGCCATCTGCATACCTTGTTGATGTGCAAGATTATGAATTCATGCAGCGTCGGCTTGAGC
TGCTTGAGGGGCTCTCTCGGGGAGAGCGTGCTGTACTTGAGGGAAGAACGTATAGCCAAAGTGAGGCCAGAGAGAAAATG
AGTAAATGGCTGAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1I1I6C4