Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4088369..4088988 Replicon chromosome
Accession NZ_CP037742
Organism Klebsiella pneumoniae strain ST23

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag E1A84_RS19910 Protein ID WP_002892050.1
Coordinates 4088770..4088988 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag E1A84_RS19905 Protein ID WP_002892066.1
Coordinates 4088369..4088743 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E1A84_RS19895 4083521..4084714 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
E1A84_RS19900 4084737..4087883 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
E1A84_RS19905 4088369..4088743 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
E1A84_RS19910 4088770..4088988 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
E1A84_RS19915 4089147..4089713 + 567 WP_002892030.1 maltose O-acetyltransferase -
E1A84_RS28955 4089685..4089825 - 141 WP_004147370.1 hypothetical protein -
E1A84_RS19920 4089846..4090316 + 471 WP_002892026.1 YlaC family protein -
E1A84_RS19925 4090291..4091742 - 1452 WP_014907971.1 PLP-dependent aminotransferase family protein -
E1A84_RS19930 4091843..4092541 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
E1A84_RS19935 4092538..4092678 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
E1A84_RS19940 4092678..4092941 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T119994 WP_002892050.1 NZ_CP037742:4088770-4088988 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T119994 NZ_CP037742:4088770-4088988 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT119994 WP_002892066.1 NZ_CP037742:4088369-4088743 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT119994 NZ_CP037742:4088369-4088743 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References