Detailed information of TA system TA119984

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 796416..797073
• Replicon: chromosome
• Accession: NZ_CP037742
• Organism: Klebsiella pneumoniae strain ST23

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: E1A84_RS03975
• Protein ID: WP_136686442.1
• Coordinates: 796663..797073 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: E1A84_RS03970
• Protein ID: WP_002916312.1
• Coordinates: 796416..796682 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E1A84_RS03945	791624..793057	-	1434	WP_002916322.1	6-phospho-beta-glucosidase BglA	-
E1A84_RS03950	793176..793904	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
E1A84_RS03955	793954..794265	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
E1A84_RS03960	794429..795088	+	660	WP_002916317.1	hemolysin III family protein	-
E1A84_RS03965	795187..796170	-	984	WP_014906951.1	tRNA-modifying protein YgfZ	-
E1A84_RS03970	796416..796682	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
E1A84_RS03975	796663..797073	+	411	WP_136686442.1	protein YgfX	Toxin
E1A84_RS03980	797080..797601	-	522	WP_002916308.1	flavodoxin FldB	-
E1A84_RS03985	797702..798598	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
E1A84_RS03990	798621..799334	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
E1A84_RS03995	799340..801073	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16021.80 Da
• Isoelectric Point: 11.1733

>T119984 WP_136686442.1 NZ_CP037742:796663-797073 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQQRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T119984 NZ_CP037742:796663-797073 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCAGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT119984 WP_002916312.1 NZ_CP037742:796416-796682 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT119984 NZ_CP037742:796416-796682 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41