Detailed information of TA system TA119952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 24674..25682
• Replicon: plasmid pFM-G13
• Accession: NZ_CP037428
• Organism: Myroides odoratimimus strain G13

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: E0Z07_RS17905
• Protein ID: WP_131541122.1
• Coordinates: 25119..25682 (+)
• Length: 188 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: E0Z07_RS17900
• Protein ID: WP_131541121.1
• Coordinates: 24674..25129 (+)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0Z07_RS17870	20595..21392	+	798	WP_131541115.1	hypothetical protein	-
E0Z07_RS17875	21628..21804	+	177	WP_131541116.1	histone H1	-
E0Z07_RS17880	22002..22340	+	339	WP_131541117.1	hypothetical protein	-
E0Z07_RS17885	22343..22807	-	465	WP_131541118.1	S24 family peptidase	-
E0Z07_RS17890	22804..24057	-	1254	WP_131541119.1	Y-family DNA polymerase	-
E0Z07_RS17895	24103..24558	+	456	WP_131541120.1	hypothetical protein	-
E0Z07_RS17900	24674..25129	+	456	WP_131541121.1	helix-turn-helix domain-containing protein	Antitoxin
E0Z07_RS17905	25119..25682	+	564	WP_131541122.1	PIN domain-containing protein	Toxin
E0Z07_RS17910	25808..26371	+	564	WP_131541123.1	recombinase family protein	-
E0Z07_RS17915	26427..26816	+	390	WP_131541124.1	hypothetical protein	-
E0Z07_RS17920	26821..27810	+	990	WP_131541125.1	WYL domain-containing protein	-
E0Z07_RS17925	27871..30327	+	2457	WP_131541126.1	N-6 DNA methylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..43223	43223

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-114)

Antitoxin

• Helix-turn-helix domain, group 17 (81-127)

Sequences

Toxin

Protein

• Length: 188 a.a.
• Molecular weight: 21440.74 Da
• Isoelectric Point: 5.2668

>T119952 WP_131541122.1 NZ_CP037428:25119-25682 [Myroides odoratimimus]
MIHSVRYKAVLDTNVIFPIVIRDLLFWFAHYDLYTPKWSKIIFDEWKSVMIRKGVESSQAEKRINVANLAFPDALVLNYE
GLIDNLNLPDKDDRHVLAAAIKVNANIIVTNNLKDFPDDYLDSFGLKAVCADDFLTDIIDLNPKIALQAFKDLVLNRKNP
AMDEFQVLESFRKNGLNQTADYLHALL

Nucleotide

• Length: 564 bp

>T119952 NZ_CP037428:25119-25682 [Myroides odoratimimus]
ATGATTCATAGTGTACGATACAAAGCTGTTCTTGATACCAATGTAATATTTCCTATCGTGATTAGAGATTTATTATTTTG
GTTTGCTCATTATGATTTATATACCCCAAAATGGAGTAAAATCATTTTTGATGAATGGAAATCTGTAATGATTCGAAAGG
GAGTTGAATCTTCCCAAGCAGAGAAGCGGATAAACGTTGCAAATTTGGCATTTCCCGATGCTTTAGTACTAAATTATGAA
GGTTTAATTGATAATTTAAATTTACCTGATAAAGATGATAGACATGTATTAGCTGCTGCTATTAAAGTCAATGCCAATAT
TATTGTAACTAATAACTTAAAGGATTTTCCAGATGATTATTTAGACTCTTTTGGATTGAAGGCAGTTTGTGCGGATGATT
TTCTTACAGATATCATTGATTTAAATCCAAAAATAGCCCTCCAAGCTTTTAAAGATTTGGTATTAAATCGCAAAAACCCG
GCAATGGATGAATTTCAAGTATTAGAAAGTTTTAGAAAAAATGGATTAAATCAAACAGCAGATTATTTACATGCTTTATT
GTAA

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 17423.16 Da
• Isoelectric Point: 5.7617

>AT119952 WP_131541121.1 NZ_CP037428:24674-25129 [Myroides odoratimimus]
METLDYIKRPTKKEQRVAIESYSALSSILSQLKNDDTEIEIEETNDRIKIPFKALKLLSEILKSMSEGNPISIVPIATEV
TTQKAAEILGCSRPHLVKLLEQGEIDFTMVGRHRRILFEDVIKYKNEMKQKQKKHIIDIMNFDDEIGLYDS

Nucleotide

• Length: 456 bp

>AT119952 NZ_CP037428:24674-25129 [Myroides odoratimimus]
ATGGAAACATTAGACTATATAAAAAGACCCACTAAGAAAGAACAACGAGTGGCTATTGAATCTTATTCAGCACTTTCTTC
AATTTTATCACAATTGAAGAATGATGATACAGAAATAGAAATCGAAGAAACAAATGACAGAATTAAAATACCTTTTAAAG
CTTTAAAGCTTTTAAGTGAAATTTTGAAGTCAATGAGTGAAGGAAATCCAATATCTATTGTACCTATTGCAACGGAAGTC
ACTACTCAAAAAGCAGCTGAAATATTGGGTTGTTCAAGACCTCATTTAGTTAAACTTTTAGAGCAAGGCGAAATTGATTT
TACAATGGTTGGAAGACATCGTCGTATTTTATTTGAAGATGTAATCAAATATAAAAACGAAATGAAGCAAAAACAGAAAA
AGCATATCATTGATATTATGAACTTTGATGATGAAATAGGTTTATATGATTCATAG