Detailed information of TA system TA119951

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3288016..3288665
• Replicon: chromosome
• Accession: NZ_CP037424
• Organism: Acinetobacter johnsonii strain M19

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: E0Z08_RS16290
• Protein ID: WP_078426173.1
• Coordinates: 3288016..3288402 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9CU98
• Locus tag: E0Z08_RS16295
• Protein ID: WP_004977895.1
• Coordinates: 3288408..3288665 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0Z08_RS16275	3283349..3285631	-	2283	WP_131230654.1	TRAP transporter large permease subunit	-
E0Z08_RS16280	3285814..3286386	-	573	WP_131230655.1	rhombosortase	-
E0Z08_RS16285	3286458..3287495	-	1038	WP_131230657.1	hypothetical protein	-
E0Z08_RS16290	3288016..3288402	-	387	WP_078426173.1	hypothetical protein	Toxin
E0Z08_RS16295	3288408..3288665	-	258	WP_004977895.1	succinate dehydrogenase assembly factor 2	Antitoxin
E0Z08_RS16300	3288858..3290030	+	1173	WP_131230659.1	acyl-CoA dehydrogenase family protein	-
E0Z08_RS16305	3290065..3290856	-	792	WP_078426171.1	alpha/beta hydrolase	-
E0Z08_RS16310	3290995..3292482	-	1488	WP_131230660.1	NAD(P)/FAD-dependent oxidoreductase	-
E0Z08_RS16315	3292678..3293043	-	366	WP_004691290.1	50S ribosomal protein L17	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (5-127)

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15302.28 Da
• Isoelectric Point: 10.4419

>T119951 WP_078426173.1 NZ_CP037424:c3288402-3288016 [Acinetobacter johnsonii]
MEHRHFQLKPSRLAYVFQLSIYAVLMLVLYQLLPLGVWLIALVAGFVLYLFFLRGPQHFQLQHLDGRDWSLSLQKQTNVQ
RVQISHIVDHRAYIVIYFQHFRAKPMLVWCDQLPITQWKALKILTKMQ

Nucleotide

• Length: 387 bp

>T119951 NZ_CP037424:c3288402-3288016 [Acinetobacter johnsonii]
ATGGAACATCGTCATTTTCAACTTAAACCCAGCCGTCTGGCTTATGTGTTTCAGTTGTCGATTTATGCCGTTCTGATGCT
GGTCTTGTATCAGCTACTTCCTTTAGGAGTGTGGCTGATTGCTTTGGTTGCAGGCTTTGTGCTGTATTTGTTTTTTCTAC
GTGGGCCGCAACATTTTCAGCTTCAGCATTTAGATGGCCGTGATTGGTCTTTGTCACTTCAGAAACAAACCAATGTGCAA
CGAGTGCAAATCAGCCATATTGTGGATCATCGTGCTTATATTGTGATTTATTTTCAACACTTTAGAGCAAAACCGATGTT
GGTTTGGTGTGATCAGTTACCCATCACGCAATGGAAAGCCCTGAAAATACTCACTAAAATGCAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.71 Da
• Isoelectric Point: 4.7119

>AT119951 WP_004977895.1 NZ_CP037424:c3288665-3288408 [Acinetobacter johnsonii]
MTEEMSLEERKVIYRARRGLKEIDVYFDPYVKNYYLQADPAEKAMFAALVEQEDPDLLDWFMEVSEPPRPEMKTLIQKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT119951 NZ_CP037424:c3288665-3288408 [Acinetobacter johnsonii]
ATGACTGAAGAAATGAGCTTGGAAGAACGTAAAGTAATCTACCGTGCACGTCGTGGTTTAAAAGAAATTGATGTGTATTT
TGACCCTTATGTGAAAAATTATTATCTTCAGGCAGATCCTGCGGAAAAGGCCATGTTTGCGGCCTTGGTTGAACAAGAAG
ATCCAGATTTGTTGGATTGGTTTATGGAAGTCTCTGAGCCGCCCCGCCCTGAAATGAAAACCTTGATTCAAAAATTAAAG
CATTATGTACACGGATAA

Structures

Antitoxin

• AlphaFold DB: N9CU98