Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3043803..3044452 Replicon chromosome
Accession NZ_CP037424
Organism Acinetobacter johnsonii strain M19

Toxin (Protein)


Gene name vapC Uniprot ID A0A0U3RPE6
Locus tag E0Z08_RS15085 Protein ID WP_010327421.1
Coordinates 3043803..3044222 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0U3RE63
Locus tag E0Z08_RS15090 Protein ID WP_010327422.1
Coordinates 3044222..3044452 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E0Z08_RS15050 3039687..3040082 - 396 WP_010327416.1 VOC family protein -
E0Z08_RS15055 3040672..3040944 - 273 WP_010327417.1 hypothetical protein -
E0Z08_RS15060 3041051..3041749 - 699 WP_010327418.1 hypothetical protein -
E0Z08_RS15065 3041962..3042315 + 354 WP_010327419.1 hypothetical protein -
E0Z08_RS15070 3042397..3042603 - 207 WP_004695205.1 hypothetical protein -
E0Z08_RS15075 3042835..3043410 - 576 WP_010327420.1 DUF4126 domain-containing protein -
E0Z08_RS15080 3043529..3043672 - 144 WP_004695201.1 zinc ribbon-containing protein -
E0Z08_RS15085 3043803..3044222 - 420 WP_010327421.1 type II toxin-antitoxin system VapC family toxin Toxin
E0Z08_RS15090 3044222..3044452 - 231 WP_010327422.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
E0Z08_RS15095 3044525..3045463 - 939 WP_010327423.1 hypothetical protein -
E0Z08_RS15100 3045468..3045689 - 222 WP_010327424.1 hypothetical protein -
E0Z08_RS15105 3045769..3048375 - 2607 WP_010327425.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
E0Z08_RS15110 3048637..3049359 + 723 WP_010327426.1 GcvT-like aminomethyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16150.51 Da        Isoelectric Point: 6.2193

>T119950 WP_010327421.1 NZ_CP037424:c3044222-3043803 [Acinetobacter johnsonii]
MQTQYLLDTNICIYIIKHQPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQQKEKALKVIDELTSMIQVVELDEYVA
DHYAQIRQDLSSKGQIIGANDLWLAAHARANNWVMVTNNEKEFLRVDGLQIENWVTNTL

Download         Length: 420 bp

>T119950 NZ_CP037424:c3044222-3043803 [Acinetobacter johnsonii]
ATGCAGACACAATATTTATTGGATACGAATATTTGTATCTACATCATCAAACATCAACCTGAAATTGTCCGTCAGCATTT
TGAAAAACATCTCCCACATCGAAATATTTTAATTTCAGTCATTACTTTGGGGGAGTTGCGTTTTGGTGCAGAGAAAAGTC
AGCAAAAAGAAAAAGCCCTTAAAGTGATAGATGAATTAACCTCAATGATTCAAGTGGTTGAGTTAGATGAATATGTCGCT
GATCACTATGCGCAAATACGCCAAGACCTTTCATCTAAAGGGCAGATTATTGGTGCGAATGATTTGTGGCTTGCCGCGCA
TGCACGTGCGAATAATTGGGTGATGGTGACCAATAATGAAAAAGAATTTTTGCGTGTCGATGGATTGCAGATCGAAAATT
GGGTGACTAACACCTTGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9023.27 Da        Isoelectric Point: 4.6936

>AT119950 WP_010327422.1 NZ_CP037424:c3044452-3044222 [Acinetobacter johnsonii]
MTTAKVFMTGRSQAVRLPKEFRFEGTEVEIFRRGDDVILREKPVTVDRLFKVLAQMPNDFYAEERVDEPPQEREEF

Download         Length: 231 bp

>AT119950 NZ_CP037424:c3044452-3044222 [Acinetobacter johnsonii]
ATGACTACCGCAAAAGTTTTTATGACTGGTCGAAGCCAAGCTGTTCGCTTACCCAAAGAATTTCGCTTTGAAGGTACAGA
AGTCGAAATTTTCCGTCGTGGCGATGACGTGATTCTGCGTGAAAAGCCAGTCACCGTAGATCGGTTATTTAAAGTATTAG
CGCAAATGCCGAATGACTTTTATGCAGAAGAAAGAGTGGATGAACCACCACAGGAACGAGAAGAGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U3RPE6

Antitoxin

Source ID Structure
AlphaFold DB A0A0U3RE63

References