Detailed information of TA system TA119944

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4116331..4116959
• Replicon: chromosome
• Accession: NZ_CP036534
• Organism: Streptomyces sp. VN1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A6G9EWQ1
• Locus tag: EZV63_RS18295
• Protein ID: WP_037763980.1
• Coordinates: 4116549..4116959 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: EZV63_RS18290
• Protein ID: WP_031046014.1
• Coordinates: 4116331..4116552 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZV63_RS18265	4111642..4112004	-	363	WP_166624516.1	hypothetical protein	-
EZV63_RS18270	4112301..4113173	+	873	WP_079154978.1	peptidoglycan-binding protein	-
EZV63_RS18275	4113170..4114066	+	897	WP_166624517.1	XRE family transcriptional regulator	-
EZV63_RS18280	4114153..4115292	-	1140	WP_166624518.1	FAD-dependent monooxygenase	-
EZV63_RS18285	4115456..4116148	-	693	WP_037763977.1	TetR/AcrR family transcriptional regulator C-terminal domain-containing protein	-
EZV63_RS18290	4116331..4116552	+	222	WP_031046014.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
EZV63_RS18295	4116549..4116959	+	411	WP_037763980.1	PIN domain-containing protein	Toxin
EZV63_RS18300	4117953..4118366	-	414	WP_031046009.1	arsenate reductase ArsC	-
EZV63_RS18305	4118459..4118767	+	309	WP_019324863.1	metalloregulator ArsR/SmtB family transcription factor	-
EZV63_RS18310	4118764..4119873	+	1110	WP_037763984.1	ACR3 family arsenite efflux transporter	-
EZV63_RS18315	4119932..4120987	+	1056	WP_037763986.1	NAD(P)/FAD-dependent oxidoreductase	-
EZV63_RS18320	4120998..4121366	-	369	WP_037763989.1	metalloregulator ArsR/SmtB family transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (3-42)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 14946.55 Da
• Isoelectric Point: 4.8736

>T119944 WP_037763980.1 NZ_CP036534:4116549-4116959 [Streptomyces sp. VN1]
VMYLLDTSGLVRLLRDANLQSAWHDAIDAGAIASCYVQRTEFLYSARNRSEYDEIAEMFSDLYPDAAVPKNAGRWISAVQ
HRMAQAGEHRSASAVDLVIAATAAHHGLTVLHDDADYGTVARHASDLNEYNVNDVV

Nucleotide

• Length: 411 bp

>T119944 NZ_CP036534:4116549-4116959 [Streptomyces sp. VN1]
GTGATGTACCTGCTCGATACGTCCGGCCTGGTCAGGCTGCTCCGCGATGCGAACCTGCAATCGGCCTGGCACGACGCGAT
CGATGCCGGAGCCATCGCATCCTGCTACGTGCAACGCACCGAGTTCCTGTACAGCGCCCGGAATCGCAGCGAGTACGACG
AGATCGCGGAAATGTTCTCCGACCTCTATCCCGATGCGGCGGTGCCGAAGAATGCAGGGCGTTGGATCAGCGCGGTGCAA
CACCGTATGGCTCAGGCCGGGGAGCACCGCAGTGCCTCGGCAGTAGACCTTGTCATCGCAGCCACTGCCGCGCACCACGG
CCTGACTGTCCTCCACGACGACGCCGACTACGGCACTGTCGCCCGGCACGCATCCGACCTGAACGAGTACAACGTCAACG
ACGTCGTCTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8585.65 Da
• Isoelectric Point: 7.4050

>AT119944 WP_031046014.1 NZ_CP036534:4116331-4116552 [Streptomyces sp. VN1]
MSVTQIDIDDDALERAMALAHVRTKKEAVNLALHFYAEQQERAARISRHFERAREWGAVEDAERLHRVEKRSR

Nucleotide

• Length: 222 bp

>AT119944 NZ_CP036534:4116331-4116552 [Streptomyces sp. VN1]
ATGTCCGTGACCCAGATCGACATCGATGACGACGCCCTGGAGCGCGCCATGGCTCTGGCCCATGTCCGGACCAAGAAGGA
GGCGGTCAATCTCGCTCTGCATTTCTACGCCGAGCAGCAGGAACGTGCGGCGCGCATCAGCCGTCACTTCGAGCGTGCCC
GCGAGTGGGGTGCCGTCGAGGACGCCGAGCGCCTGCACAGGGTGGAGAAGCGCAGCCGGTGA

Structures

Toxin

• AlphaFold DB: A0A6G9EWQ1