Detailed information of TA system TA119941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumA-relB/upstrm_HI1419-dnstrm_HI1420
• Location: 2930354..2930929
• Replicon: chromosome
• Accession: NZ_CP036532
• Organism: Roseitalea porphyridii strain MA7-20

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: E0E05_RS14285
• Protein ID: WP_131617323.1
• Coordinates: 2930639..2930929 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4P6V2H7
• Locus tag: E0E05_RS14280
• Protein ID: WP_039724038.1
• Coordinates: 2930354..2930638 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E05_RS14265	2925841..2927931	-	2091	WP_131617320.1	hypothetical protein	-
E0E05_RS14270	2927970..2929268	-	1299	WP_131617321.1	adenylosuccinate synthase	-
E0E05_RS14275	2929433..2930347	+	915	WP_131617322.1	DMT family transporter	-
E0E05_RS14280	2930354..2930638	-	285	WP_039724038.1	putative addiction module antidote protein	Antitoxin
E0E05_RS14285	2930639..2930929	-	291	WP_131617323.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E0E05_RS14290	2931009..2932604	-	1596	WP_131617324.1	phosphoglycerate dehydrogenase	-
E0E05_RS14295	2932807..2933985	-	1179	WP_131617325.1	phosphoserine transaminase	-
E0E05_RS14300	2934231..2935331	-	1101	WP_131617326.1	DJ-1/PfpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Uncharacterized protein HI1420 (3-92)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10884.70 Da
• Isoelectric Point: 10.8744

>T119941 WP_131617323.1 NZ_CP036532:c2930929-2930639 [Roseitalea porphyridii]
MIEVRKTAVFERWYAGLRDVQARVRIDARIDRIGLGNFGDAKSVGSGVMELRLAFGPGYRLYYTRRHGKVVVLLCGGDKG
SQRRDIEMAKRLAKEL

Nucleotide

• Length: 291 bp

>T119941 NZ_CP036532:c2930929-2930639 [Roseitalea porphyridii]
ATGATCGAAGTGCGCAAGACGGCGGTCTTCGAAAGATGGTACGCCGGCTTGCGCGATGTTCAGGCGAGGGTCCGGATCGA
TGCCCGGATTGATCGCATCGGCCTTGGTAACTTCGGAGATGCCAAGTCGGTGGGATCGGGGGTGATGGAGCTGCGGCTCG
CCTTCGGACCCGGCTATCGGCTCTACTACACGCGCCGACACGGCAAGGTCGTCGTGCTCTTGTGCGGTGGTGACAAGGGA
TCCCAGCGAAGGGACATCGAGATGGCGAAGCGGCTGGCAAAGGAGCTCTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10014.36 Da
• Isoelectric Point: 4.2815

>AT119941 WP_039724038.1 NZ_CP036532:c2930638-2930354 [Roseitalea porphyridii]
MVLETTRWDTAESLRSPEYIAAYLEVVFEEGDPAHIGLALDNVARSEGLGEIARKAGVSREALAAALTDEGDPRLSTFIG
VMKALGLRIVAEAA

Nucleotide

• Length: 285 bp

>AT119941 NZ_CP036532:c2930638-2930354 [Roseitalea porphyridii]
ATGGTCCTCGAAACCACCCGGTGGGATACGGCAGAAAGCCTGCGATCGCCCGAGTACATCGCGGCTTACCTCGAAGTGGT
GTTCGAAGAGGGCGATCCGGCGCATATTGGGCTGGCGCTCGACAATGTCGCCCGCTCCGAGGGGCTCGGCGAGATCGCCC
GCAAGGCCGGGGTTTCCCGTGAGGCACTCGCCGCGGCGCTGACCGATGAGGGCGACCCCAGGCTGAGCACGTTCATCGGC
GTGATGAAGGCGCTCGGCCTCAGAATCGTCGCCGAGGCCGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A4P6V2H7