Detailed information of TA system TA119938

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2596251..2596731
• Replicon: chromosome
• Accession: NZ_CP036532
• Organism: Roseitalea porphyridii strain MA7-20

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: E0E05_RS12685
• Protein ID: WP_131617046.1
• Coordinates: 2596459..2596731 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: E0E05_RS12680
• Protein ID: WP_131617045.1
• Coordinates: 2596251..2596475 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E0E05_RS17385	2591439..2591600	+	162	WP_158629363.1	hypothetical protein	-
E0E05_RS12655	2591676..2592392	+	717	WP_131617041.1	haloacid dehalogenase type II	-
E0E05_RS12660	2592488..2593498	+	1011	WP_131617042.1	GlxA family transcriptional regulator	-
E0E05_RS12665	2593519..2594346	+	828	WP_131617043.1	substrate-binding domain-containing protein	-
E0E05_RS12670	2594350..2595015	-	666	WP_131618030.1	ABC transporter permease	-
E0E05_RS12675	2595235..2596068	-	834	WP_131617044.1	DUF1194 domain-containing protein	-
E0E05_RS12680	2596251..2596475	+	225	WP_131617045.1	ribbon-helix-helix protein, CopG family	Antitoxin
E0E05_RS12685	2596459..2596731	+	273	WP_131617046.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E0E05_RS12690	2596863..2599421	+	2559	WP_131617047.1	FAD-dependent oxidoreductase	-
E0E05_RS12695	2599545..2601257	+	1713	WP_131617048.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-88)

Antitoxin

• Ribbon-helix-helix protein, CopG (6-38)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10553.24 Da
• Isoelectric Point: 11.7374

>T119938 WP_131617046.1 NZ_CP036532:2596459-2596731 [Roseitalea porphyridii]
MVWRIELSETAGRRLSKLPKADAKRITGFLRDRLASRDDPRSIGTPLKGNRYADLWRYRVGDYRLIAQVRDATLTILIVD
LGHRSRIYRR

Nucleotide

• Length: 273 bp

>T119938 NZ_CP036532:2596459-2596731 [Roseitalea porphyridii]
TTGGTCTGGCGGATTGAACTGTCCGAGACGGCGGGCAGGCGACTGTCGAAACTGCCCAAGGCCGATGCGAAGCGGATCAC
CGGTTTTCTGCGCGACCGGCTCGCAAGTCGCGACGATCCCCGATCGATCGGTACGCCGCTCAAGGGAAACCGCTACGCGG
ACCTCTGGCGCTACCGTGTCGGCGACTACAGGCTGATCGCGCAGGTTCGGGACGCGACCCTGACCATCCTCATCGTCGAC
CTCGGCCATCGGAGCCGGATCTACCGACGTTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8298.43 Da
• Isoelectric Point: 4.1426

>AT119938 WP_131617045.1 NZ_CP036532:2596251-2596475 [Roseitalea porphyridii]
MNWIILPPDLERRVDELARRSGKPTEELVRLALMQGIEDIEDAIAAEVVLDRIGKGEERTETLSDVEARLGLAD

Nucleotide

• Length: 225 bp

>AT119938 NZ_CP036532:2596251-2596475 [Roseitalea porphyridii]
ATGAATTGGATCATTCTGCCCCCCGATCTCGAGCGCCGTGTGGACGAACTCGCCAGACGCAGCGGCAAGCCGACCGAAGA
GCTGGTGCGGCTGGCATTGATGCAGGGGATCGAGGATATCGAGGACGCGATCGCCGCCGAGGTGGTCCTCGACAGGATCG
GGAAGGGCGAAGAGAGGACCGAAACCCTGTCGGACGTCGAGGCGAGGCTTGGTCTGGCGGATTGA