Detailed information of TA system TA119935

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1507920..1508532
• Replicon: chromosome
• Accession: NZ_CP036531
• Organism: Streptococcus pyogenes strain STAB10048

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: EZ612_RS07455
• Protein ID: WP_002994716.1
• Coordinates: 1508197..1508532 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q5X9X9
• Locus tag: EZ612_RS07450
• Protein ID: WP_002988079.1
• Coordinates: 1507920..1508207 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZ612_RS07425	1503110..1504093	-	984	WP_031488719.1	tagatose-bisphosphate aldolase	-
EZ612_RS07430	1504097..1505026	-	930	WP_031488720.1	tagatose-6-phosphate kinase	-
EZ612_RS07435	1505074..1505589	-	516	WP_002991700.1	galactose-6-phosphate isomerase subunit LacB	-
EZ612_RS07440	1505624..1506052	-	429	WP_014635709.1	galactose-6-phosphate isomerase subunit LacA	-
EZ612_RS07445	1506497..1507270	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
EZ612_RS07450	1507920..1508207	+	288	WP_002988079.1	DNA-damage-inducible protein J	Antitoxin
EZ612_RS07455	1508197..1508532	+	336	WP_002994716.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EZ612_RS08590	1508684..1509154	+	471	WP_021733374.1	site-specific integrase	-
EZ612_RS08595	1509117..1509665	+	549	WP_180372715.1	site-specific integrase	-
EZ612_RS07470	1509797..1510189	-	393	WP_002982716.1	30S ribosomal protein S9	-
EZ612_RS07475	1510210..1510656	-	447	WP_002982710.1	50S ribosomal protein L13	-
EZ612_RS07480	1510874..1511080	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
EZ612_RS07485	1511077..1511583	-	507	WP_002988070.1	hypothetical protein	-
EZ612_RS07490	1511719..1512579	-	861	WP_011529009.1	DegV family protein	-
EZ612_RS07495	1512676..1513194	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-104)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13154.89 Da
• Isoelectric Point: 5.6157

>T119935 WP_002994716.1 NZ_CP036531:1508197-1508532 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Nucleotide

• Length: 336 bp

>T119935 NZ_CP036531:1508197-1508532 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10934.56 Da
• Isoelectric Point: 5.2318

>AT119935 WP_002988079.1 NZ_CP036531:1507920-1508207 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT119935 NZ_CP036531:1507920-1508207 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4U7GX94