Detailed information of TA system TA119933

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FaRel2-ATfaRel2/-
• Location: 1199443..1200265
• Replicon: chromosome
• Accession: NZ_CP036524
• Organism: [Clostridium] hylemonae DSM 15053

Toxin (Protein)

• Gene name: faRel2
• Uniprot ID: -
• Locus tag: LAJLEIBI_RS05590
• Protein ID: WP_138261968.1
• Coordinates: 1199443..1200060 (+)
• Length: 206 a.a.

Antitoxin (Protein)

• Gene name: ATfaRel2
• Uniprot ID: C0BXT4
• Locus tag: LAJLEIBI_RS05595
• Protein ID: WP_006441954.1
• Coordinates: 1200041..1200265 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAJLEIBI_RS05580	1194865..1196322	-	1458	WP_006441949.1	GntR family transcriptional regulator	-
LAJLEIBI_RS05585	1196529..1199159	+	2631	WP_050765461.1	response regulator	-
LAJLEIBI_RS05590	1199443..1200060	+	618	WP_138261968.1	hypothetical protein	Toxin
LAJLEIBI_RS05595	1200041..1200265	+	225	WP_006441954.1	hypothetical protein	Antitoxin
LAJLEIBI_RS05605	1200409..1202391	+	1983	WP_006441955.1	excinuclease ABC subunit UvrB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (66-170)

Antitoxin

• Protein of unknown function DUF6718 (1-74)

Sequences

Toxin

Protein

• Length: 206 a.a.
• Molecular weight: 24537.80 Da
• Isoelectric Point: 6.1570

>T119933 WP_138261968.1 NZ_CP036524:1199443-1200060 [[Clostridium] hylemonae DSM 15053]
IMSDILQRDGLTIELLGRLSYKSNLGINLKKNLHYFDKEKLFEELIKVNEWYDSYDELYELALDYRIKSIQSAILKYERY
YPDHQTRKVFDDMLGFRSLCDNYEDVLTLKGIPELRVADMSKGKANDDGYRGIHVYFQLDGSHYPIEIQYNTYYDRQFNN
WLHKYVYKKKYDNSVGCHLRELYEGAKILTEKDFKEALEHVLFSS

Nucleotide

• Length: 618 bp

>T119933 NZ_CP036524:1199443-1200060 [[Clostridium] hylemonae DSM 15053]
ATAATGTCAGATATCTTACAAAGGGATGGTCTTACGATAGAATTGCTTGGACGCTTGTCTTATAAGTCAAATCTAGGAAT
TAACTTAAAGAAGAATTTACATTATTTTGATAAGGAAAAGCTTTTTGAAGAACTTATAAAGGTGAATGAGTGGTATGATT
CGTATGATGAATTGTATGAATTAGCATTGGACTATAGAATTAAGAGTATTCAATCTGCAATATTGAAGTATGAAAGATAT
TATCCAGACCATCAGACCAGAAAAGTATTTGATGATATGTTAGGATTTCGTTCGCTATGTGATAATTACGAGGATGTGTT
GACATTGAAGGGAATTCCAGAGTTACGTGTGGCAGACATGTCAAAAGGAAAAGCAAATGATGATGGTTATAGAGGGATTC
ATGTGTATTTTCAATTAGATGGCAGTCATTACCCTATCGAAATACAATATAATACATATTATGACAGGCAATTTAACAAT
TGGCTTCATAAATATGTATATAAAAAGAAATATGATAATTCGGTAGGATGTCACTTGCGAGAATTATACGAAGGTGCTAA
AATTCTAACAGAAAAAGATTTTAAGGAGGCGTTAGAACATGTGTTATTTAGTAGCTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8518.72 Da
• Isoelectric Point: 5.6112

>AT119933 WP_006441954.1 NZ_CP036524:1200041-1200265 [[Clostridium] hylemonae DSM 15053]
MCYLVAKHVGEVGSVALKTTHGKHLSEFKRSIEEKVGYEKIQLVTISRPSAYGEYEPYYFADTEEEFEKLVINM

Nucleotide

• Length: 225 bp

>AT119933 NZ_CP036524:1200041-1200265 [[Clostridium] hylemonae DSM 15053]
ATGTGTTATTTAGTAGCTAAACATGTAGGTGAAGTCGGAAGTGTTGCATTAAAAACAACACATGGGAAACATCTTTCAGA
GTTTAAAAGATCAATAGAGGAAAAAGTTGGATATGAAAAAATTCAACTTGTTACTATCAGTAGACCTTCAGCTTATGGAG
AATATGAACCGTATTATTTTGCGGATACGGAGGAAGAATTTGAAAAACTTGTTATAAATATGTAG

Structures

Antitoxin

• AlphaFold DB: C0BXT4