Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 26813..27423 Replicon plasmid p_unnamed2
Accession NZ_CP036517
Organism Lichenihabitans psoromatis strain PAMC 29148

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag EY713_RS22535 Protein ID WP_131120390.1
Coordinates 26813..27112 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag EY713_RS22540 Protein ID WP_131120392.1
Coordinates 27115..27423 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EY713_RS22505 22008..22331 - 324 WP_131120380.1 hypothetical protein -
EY713_RS22510 22394..23158 - 765 WP_131120411.1 aldo/keto reductase -
EY713_RS22515 23256..23837 + 582 WP_131120382.1 TetR/AcrR family transcriptional regulator -
EY713_RS22520 24297..24710 + 414 WP_131120384.1 helix-turn-helix transcriptional regulator -
EY713_RS22525 24749..25006 + 258 WP_131120386.1 hypothetical protein -
EY713_RS22530 25499..26233 + 735 WP_165491262.1 recombinase family protein -
EY713_RS22535 26813..27112 + 300 WP_131120390.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EY713_RS22540 27115..27423 + 309 WP_131120392.1 putative addiction module antidote protein Antitoxin
EY713_RS22545 27420..27674 - 255 WP_131120393.1 hypothetical protein -
EY713_RS22550 28367..28666 - 300 Protein_34 transposase -
EY713_RS22555 28824..29894 + 1071 WP_131120395.1 HAD family hydrolase -
EY713_RS22560 30303..30590 - 288 WP_131120397.1 hypothetical protein -
EY713_RS22565 31024..32130 + 1107 WP_131120399.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..38445 38445
- flank IS/Tn - - 28367..28666 299


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(10-95)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11010.72 Da        Isoelectric Point: 7.9749

>T119930 WP_131120390.1 NZ_CP036517:26813-27112 [Lichenihabitans psoromatis]
MPFEVRQTLEFQAWLADLRDERTQAKIAQRLVRIEAGLLGDAKPVGEGVSELRIDWGPGYRVYFVRRGQAVIVLLCGGDK
DSQTRDIKVAKVLAVGLEG

Download         Length: 300 bp

>T119930 NZ_CP036517:26813-27112 [Lichenihabitans psoromatis]
ATGCCGTTTGAAGTGCGTCAGACCCTCGAATTCCAGGCATGGCTAGCCGATCTCCGGGACGAGCGCACACAAGCTAAAAT
CGCTCAGCGCCTAGTTCGGATCGAGGCCGGTCTGCTCGGCGACGCCAAGCCTGTTGGTGAAGGTGTGAGCGAACTACGGA
TCGACTGGGGCCCGGGATACCGGGTTTATTTTGTGAGGCGCGGCCAGGCCGTGATCGTGCTGCTCTGTGGCGGCGACAAG
GATAGCCAAACCCGGGACATCAAGGTCGCAAAGGTCTTAGCCGTCGGATTGGAAGGTTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10833.32 Da        Isoelectric Point: 5.7996

>AT119930 WP_131120392.1 NZ_CP036517:27115-27423 [Lichenihabitans psoromatis]
MVHASKTETVPFDAALYLITTESQVELLSDALQTGDPSYIATALGTIARARGMAEVARDANVTREGLYKSLSSTGDPRLS
TLMGVMKALNLEFRAVSAGNRA

Download         Length: 309 bp

>AT119930 NZ_CP036517:27115-27423 [Lichenihabitans psoromatis]
ATGGTTCACGCATCAAAGACTGAAACTGTACCGTTCGACGCCGCGCTCTACCTGATCACCACGGAGTCACAGGTCGAGCT
CCTATCGGACGCCCTTCAAACAGGAGATCCCAGCTATATCGCGACGGCTCTCGGCACAATCGCCCGCGCCCGTGGGATGG
CTGAGGTTGCCCGGGACGCGAATGTCACACGCGAAGGCCTGTACAAGTCCCTATCGTCTACCGGCGACCCCCGCTTGAGC
ACCCTGATGGGCGTGATGAAAGCGCTTAACCTGGAGTTCCGGGCGGTCTCGGCAGGTAACCGGGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References