Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 740236..740896 Replicon chromosome
Accession NZ_CP036514
Organism Hafnia alvei strain PCM_1220

Toxin (Protein)


Gene name cptA Uniprot ID A0A097QZ25
Locus tag EYZ02_RS03490 Protein ID WP_025801622.1
Coordinates 740483..740896 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A097QZ09
Locus tag EYZ02_RS03485 Protein ID WP_025801623.1
Coordinates 740236..740502 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EYZ02_RS03465 735499..736149 - 651 WP_025801627.1 hemolysin III family protein -
EYZ02_RS03470 736810..737694 + 885 WP_025801626.1 nucleoside-specific channel-forming protein Tsx -
EYZ02_RS03475 737896..738714 + 819 WP_131390596.1 shikimate 5-dehydrogenase -
EYZ02_RS03480 738868..739857 - 990 WP_131390597.1 tRNA-modifying protein YgfZ -
EYZ02_RS03485 740236..740502 + 267 WP_025801623.1 FAD assembly factor SdhE Antitoxin
EYZ02_RS03490 740483..740896 + 414 WP_025801622.1 protein YgfX Toxin
EYZ02_RS03495 740983..741501 - 519 WP_040046181.1 flavodoxin FldB -
EYZ02_RS03500 741706..742605 + 900 WP_040046379.1 site-specific tyrosine recombinase XerD -
EYZ02_RS03505 742633..743349 + 717 WP_025801619.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EYZ02_RS03510 743355..745088 + 1734 WP_025801618.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16226.00 Da        Isoelectric Point: 8.5166

>T119911 WP_025801622.1 NZ_CP036514:740483-740896 [Hafnia alvei]
VDQWRCDVRVSWRTQLLLLVTHGILILLILLAPWPENYSFYWLVLLTLVVFECIRSQKQIAKIQGEFSFLADNHIQWQQN
EWELCKTPWISDFGALLPLRSVKPQGKKKRLWIAADSLTPEAWCHLRRTLMQTHQSD

Download         Length: 414 bp

>T119911 NZ_CP036514:740483-740896 [Hafnia alvei]
GTGGACCAATGGCGTTGTGATGTACGAGTGTCATGGCGAACGCAACTCTTGTTGTTAGTTACGCATGGCATTCTGATTTT
GTTGATTTTGCTAGCACCCTGGCCGGAAAACTATAGTTTTTATTGGTTGGTGTTGCTGACTTTAGTTGTGTTTGAATGTA
TCCGCAGCCAAAAGCAGATCGCTAAGATTCAGGGAGAGTTTAGCTTTCTAGCGGATAACCATATTCAATGGCAACAGAAC
GAATGGGAGTTATGTAAGACGCCTTGGATCAGTGATTTTGGCGCATTGCTACCCTTGAGAAGTGTGAAGCCGCAGGGAAA
GAAAAAGCGTTTATGGATTGCGGCAGACAGTTTGACGCCAGAGGCGTGGTGCCATTTGCGCCGCACTTTGATGCAAACCC
ACCAGAGTGATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10345.85 Da        Isoelectric Point: 6.0684

>AT119911 WP_025801623.1 NZ_CP036514:740236-740502 [Hafnia alvei]
MDIGNKSRIHWACRRGMRELDISIMPFFEHEYDSLSDADKQTFVRLLECDDPDLFNWLMNHGSPKDPELAHMVKLIQTRN
KDRGPMAL

Download         Length: 267 bp

>AT119911 NZ_CP036514:740236-740502 [Hafnia alvei]
ATGGATATAGGAAATAAATCACGCATTCATTGGGCCTGTCGCCGCGGTATGCGTGAGCTGGATATCTCCATTATGCCGTT
TTTCGAACATGAGTATGATTCACTGAGCGATGCAGATAAACAGACATTTGTACGCTTACTTGAGTGCGACGATCCCGATC
TTTTTAATTGGCTCATGAACCACGGTTCACCCAAGGATCCTGAATTAGCGCATATGGTTAAACTTATTCAAACGCGAAAC
AAAGATCGTGGACCAATGGCGTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QZ25

Antitoxin

Source ID Structure
AlphaFold DB A0A097QZ09

References