Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 385550..386097 | Replicon | chromosome |
| Accession | NZ_CP036500 | ||
| Organism | Vibrio cholerae strain 20000 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | EZZ25_RS15975 | Protein ID | WP_000229325.1 |
| Coordinates | 385795..386097 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | EZZ25_RS15970 | Protein ID | WP_000861987.1 |
| Coordinates | 385550..385807 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EZZ25_RS15910 | 380754..380906 | + | 153 | WP_001884520.1 | DUF645 family protein | - |
| EZZ25_RS15920 | 381109..381606 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | - |
| EZZ25_RS15925 | 381603..381875 | - | 273 | WP_000246253.1 | DUF1778 domain-containing protein | - |
| EZZ25_RS15930 | 382106..382774 | + | 669 | WP_000043871.1 | hypothetical protein | - |
| EZZ25_RS15935 | 382926..383213 | + | 288 | WP_000426470.1 | hypothetical protein | - |
| EZZ25_RS19430 | 383373..383477 | + | 105 | Protein_379 | PhzF family phenazine biosynthesis protein | - |
| EZZ25_RS15940 | 383535..383969 | + | 435 | WP_000453958.1 | GNAT family N-acetyltransferase | - |
| EZZ25_RS15955 | 384124..384627 | + | 504 | WP_001898452.1 | hypothetical protein | - |
| EZZ25_RS19355 | 384819..385322 | + | 504 | WP_001898452.1 | hypothetical protein | - |
| EZZ25_RS15970 | 385550..385807 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| EZZ25_RS15975 | 385795..386097 | + | 303 | WP_000229325.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| EZZ25_RS15985 | 386482..386592 | + | 111 | WP_076025930.1 | DUF645 family protein | - |
| EZZ25_RS15990 | 386922..387146 | + | 225 | WP_161571222.1 | DUF3709 domain-containing protein | - |
| EZZ25_RS19435 | 387347..387508 | + | 162 | Protein_387 | acetyltransferase | - |
| EZZ25_RS19440 | 387594..387765 | + | 172 | Protein_388 | DUF645 family protein | - |
| EZZ25_RS16000 | 387916..388584 | + | 669 | WP_002033340.1 | hypothetical protein | - |
| EZZ25_RS16005 | 388581..388697 | + | 117 | WP_088124786.1 | DUF3265 domain-containing protein | - |
| EZZ25_RS19445 | 388803..388838 | + | 36 | WP_172884631.1 | hypothetical protein | - |
| EZZ25_RS16015 | 388856..389116 | + | 261 | WP_032468027.1 | DUF3709 domain-containing protein | - |
| EZZ25_RS16025 | 389364..389735 | + | 372 | WP_001164078.1 | nucleotide pyrophosphohydrolase | - |
| EZZ25_RS16030 | 389802..390227 | + | 426 | WP_001882332.1 | DUF1778 domain-containing protein | - |
| EZZ25_RS16035 | 390224..390757 | + | 534 | WP_000118351.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 322986..403614 | 80628 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11710.64 Da Isoelectric Point: 5.1972
>T119902 WP_000229325.1 NZ_CP036500:385795-386097 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVSPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T119902 NZ_CP036500:385795-386097 [Vibrio cholerae]
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCTCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
ATGGTTGAAATAATTTGGACGGAGCCGGCTCTATCCGACTTGAATGATATTGCTGAATACATCGCTCTTGAAAATGTCGT
GGCTGCTAAACAACTGGTGCAAACCGTTTTTACAAAAGTTGAACGTTTGGCCGATTTTCCAGAGTCTGGGCGCGTCCCTC
CAGAACTAGAACACCTCAATTATCGTGAAGTCGTTGTAAGTCCGTGTCGTGTTTTCTACAAGTATGATGATGCAAAGGTT
CGTATTCTTTTTGTTATGCGTGCGGAGCGAGATTTGCGTCGGTTAATGCTTACGAAACAGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT119902 WP_000861987.1 NZ_CP036500:385550-385807 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT119902 NZ_CP036500:385550-385807 [Vibrio cholerae]
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCTTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
ATGAAAGTAGAACTTGTGACGTCACTAAAACGTCAGGCCACTAAGATCCTTGCCGATCTTCATGATACGAAAGAGCCAGT
ATTGATAACTGAGCACGGAAAACCGTCAGCTTACCTTATTGATGTAGACGACTATGAATTTATGCAAAATCGTTTAGCGA
TCTTGGAAGGTATTGCTCGCGGAGAGCGAGCTTTAGCGGATGGTAAAGTGGTCAGCCATCAAGATGCTAAGGACAGAATG
TCAAAATGGTTGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|