Detailed information of TA system TA119895

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 76282..76810
• Replicon: chromosome
• Accession: NZ_CP036499
• Organism: Vibrio cholerae strain 20000

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: EZZ25_RS00395
• Protein ID: WP_000639510.1
• Coordinates: 76282..76572 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: EZZ25_RS00400
• Protein ID: WP_000213184.1
• Coordinates: 76562..76810 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EZZ25_RS00355	71319..71795	+	477	WP_000148678.1	DNA repair protein RadC	-
EZZ25_RS00360	71792..72220	+	429	WP_000636134.1	DUF2787 domain-containing protein	-
EZZ25_RS00365	72271..72717	+	447	WP_000065400.1	DUF2787 domain-containing protein	-
EZZ25_RS00370	72824..73810	+	987	WP_000858606.1	GTPase family protein	-
EZZ25_RS00375	73845..74486	-	642	WP_000825658.1	inovirus Gp2 family protein	-
EZZ25_RS00385	75424..75897	+	474	WP_001906491.1	hypothetical protein	-
EZZ25_RS00390	75990..76190	-	201	WP_000045911.1	AlpA family transcriptional regulator	-
EZZ25_RS00395	76282..76572	-	291	WP_000639510.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EZZ25_RS00400	76562..76810	-	249	WP_000213184.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
EZZ25_RS00405	77004..78374	-	1371	WP_000015609.1	Fic family protein	-
EZZ25_RS00415	78957..80318	+	1362	WP_000391995.1	type II toxin-antitoxin system HipA family toxin	-
EZZ25_RS00420	80315..80782	+	468	WP_001906499.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	61751..80782	19031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (12-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11113.97 Da
• Isoelectric Point: 10.5016

>T119895 WP_000639510.1 NZ_CP036499:c76572-76282 [Vibrio cholerae]
MIYKLSFKKSALKEWQKLGATLQQQFKKKLAERLENPHVPASKLSGADNVYKIKLRQSGYRLVYNVEDDVVIVTVLAVGK
RERSDVYRKAMTRLDD

Nucleotide

• Length: 291 bp

>T119895 NZ_CP036499:c76572-76282 [Vibrio cholerae]
ATGATCTATAAGCTCAGTTTCAAAAAGAGTGCGCTTAAAGAATGGCAGAAGCTGGGCGCTACGCTGCAACAGCAGTTTAA
GAAAAAACTGGCGGAGCGGCTAGAGAATCCCCACGTTCCCGCTTCTAAGCTCTCTGGCGCTGACAATGTTTACAAAATCA
AGCTGCGCCAGTCTGGATACCGTTTGGTTTACAATGTGGAAGATGACGTCGTTATTGTCACTGTGTTAGCGGTAGGTAAG
CGTGAGCGCAGCGATGTTTACCGTAAAGCGATGACGCGGTTAGATGACTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9130.40 Da
• Isoelectric Point: 3.9610

>AT119895 WP_000213184.1 NZ_CP036499:c76810-76562 [Vibrio cholerae]
MTTRILADVAASITELKANPMKVANSAYGEPVAVLNRNEPVFYCVPAEAYELMMDRLEDLELLAIARERESEESISVNID
DL

Nucleotide

• Length: 249 bp

>AT119895 NZ_CP036499:c76810-76562 [Vibrio cholerae]
ATGACCACTAGAATTTTGGCTGATGTGGCTGCCAGTATCACTGAACTTAAAGCGAACCCGATGAAAGTAGCGAATAGTGC
TTATGGCGAGCCTGTTGCCGTGCTAAACCGCAATGAGCCCGTGTTTTACTGTGTGCCTGCTGAAGCGTATGAGTTGATGA
TGGACCGACTTGAAGATCTTGAGTTACTGGCCATTGCGAGAGAGCGTGAGTCAGAAGAAAGCATCTCGGTAAATATTGAT
GATCTATAA