Detailed information of TA system TA119893

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 4829582..4830144
• Replicon: chromosome
• Accession: NZ_CP036498
• Organism: Rhodopseudomonas sp. SK50-23

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: RPMA_RS23130
• Protein ID: WP_211910009.1
• Coordinates: 4829582..4829953 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: RPMA_RS23135
• Protein ID: WP_211910010.1
• Coordinates: 4829950..4830144 (-)
• Length: 65 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RPMA_RS23095 (RPMA_22830)	4824636..4825520	-	885	WP_211910003.1	alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase PhnJ	-
RPMA_RS23100 (RPMA_22835)	4825517..4826626	-	1110	WP_211910004.1	carbon-phosphorus lyase complex subunit PhnI	-
RPMA_RS23105 (RPMA_22840)	4826629..4827237	-	609	WP_211910005.1	phosphonate C-P lyase system protein PhnH	-
RPMA_RS23110 (RPMA_22845)	4827240..4827653	-	414	WP_249225361.1	phosphonate C-P lyase system protein PhnG	-
RPMA_RS23115 (RPMA_22850)	4827827..4828561	+	735	WP_211910006.1	phosphonate metabolism transcriptional regulator PhnF	-
RPMA_RS23120 (RPMA_22855)	4828577..4829044	-	468	WP_211910007.1	nuclear transport factor 2 family protein	-
RPMA_RS23125 (RPMA_22860)	4829128..4829529	-	402	WP_249225751.1	tol-pal system-associated acyl-CoA thioesterase	-
RPMA_RS23130 (RPMA_22865)	4829582..4829953	-	372	WP_211910009.1	type II toxin-antitoxin system VapC family toxin	Toxin
RPMA_RS23135 (RPMA_22870)	4829950..4830144	-	195	WP_211910010.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
RPMA_RS23140 (RPMA_22875)	4830207..4831253	-	1047	WP_211910011.1	Holliday junction branch migration DNA helicase RuvB	-
RPMA_RS23145 (RPMA_22880)	4831421..4832038	-	618	WP_211910012.1	Holliday junction branch migration protein RuvA	-
RPMA_RS23150 (RPMA_22885)	4832250..4832774	-	525	WP_211910013.1	crossover junction endodeoxyribonuclease RuvC	-
RPMA_RS23155 (RPMA_22890)	4833597..4834343	-	747	WP_211910014.1	YebC/PmpR family DNA-binding transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-46)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13783.12 Da
• Isoelectric Point: 6.8803

>T119893 WP_211910009.1 NZ_CP036498:c4829953-4829582 [Rhodopseudomonas sp. SK50-23]
MILPDTSVWIDHFRGGEKLLAPLLRSEDLLLHPFVIGELAVGPLPRRADTIRRLKLQIQAPIIDPPDVLAFIEQHALFGR
GLSYVDVQLLASVHALVNTRLWTTDKRLDIAADQLGIAYKSKE

Nucleotide

• Length: 372 bp

>T119893 NZ_CP036498:c4829953-4829582 [Rhodopseudomonas sp. SK50-23]
ATGATCCTCCCCGATACATCGGTCTGGATCGATCATTTTCGCGGCGGCGAAAAGCTGCTGGCGCCGCTTCTTCGCAGCGA
AGATCTGTTGTTGCATCCTTTTGTCATCGGGGAGCTCGCGGTCGGGCCTCTGCCGCGTCGCGCAGACACGATCAGGCGAC
TTAAGCTGCAGATACAGGCTCCGATCATTGATCCACCCGACGTCCTTGCTTTTATCGAGCAACACGCGCTTTTCGGTCGT
GGCCTCAGCTATGTTGATGTTCAGCTGCTAGCCTCGGTTCATGCGCTCGTGAATACCCGGTTATGGACAACGGACAAGCG
GCTTGATATCGCGGCCGATCAGCTCGGGATTGCGTACAAGTCCAAGGAATAG

Antitoxin

Protein

• Length: 65 a.a.
• Molecular weight: 7220.08 Da
• Isoelectric Point: 4.7361

>AT119893 WP_211910010.1 NZ_CP036498:c4830144-4829950 [Rhodopseudomonas sp. SK50-23]
MNTTVVVDGKLLDQAREYSDALENSELVQEALRAFIRREAARHLADLGGSMPDAEAPPRRRWEP

Nucleotide

• Length: 195 bp

>AT119893 NZ_CP036498:c4830144-4829950 [Rhodopseudomonas sp. SK50-23]
ATGAATACAACTGTTGTTGTGGACGGTAAATTACTCGATCAGGCGCGCGAATATAGCGATGCGTTGGAGAACTCCGAGCT
CGTCCAAGAAGCTCTGAGAGCATTCATTCGGCGCGAGGCCGCTAGGCATCTTGCTGACCTTGGCGGCTCGATGCCCGATG
CCGAAGCGCCGCCTCGTCGTAGATGGGAGCCATGA